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Stephen B. Tatter, M.D., Ph.D., Assistant Professor

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Brain Tumor Center







Stephen B. Tatter, M.D., Ph.D.
Director, Brain Tumor Center of Excellence
Co-director,
Gamma Knife Radiosurgery Center
Attending Neurosurgeon
Wake Forest University School of Medicine

Office:

(336) 716-4047
Department of Neurosurgery
Wake Forest University School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157-1029

After Hours:

(336) 716-4081

facsimile:

(336) 716-3065


Academic Background

Residency/Fellowship:

Neurosurgery
Massachusetts General Hospital
Harvard Medical School

MD/PhD Degrees:

Cornell University Medical College/
The Rockefeller University

Undergraduate:

The University of Michigan
Ann Arbor

Special Clinical Interests:

Brain and Pituitary Tumors,
Stereotactic (Image-guided) Neurosurgery,
Gamma Knife and Fractionated Linear Accelerator (LINAC) Radiosurgery,
Parkinson's Disease, Tremor, & Dystonia
Trigeminal Neuralgia & Hemifacial Spasm

Clinical Interests:

Selected Publications:


Tatter SB, Shaw EG, deGuzman A, Rosenblum ML, Mikkelson T, Olivi A, Grossman S, for the NABTT CNS Consortium. Brachytherapy in re-resected malignant glioma cavities using the GliaSite Radiotherapy System: A phase I safety and device performance trial. Proc Am Soc Clin Oncol 19:160a, 2000.

Olivi A, Barker F, Tatter S, Bruce J, Judy K, Engelhard H, Burak E, Hilt D, Grossman S, Fisher JD, Piantadosi S for the NABTT CNS Consortium and Guilford Pharmaceuticals, Inc (2000). Results of a phase I study of interstitial BCNU administered via wafers to patients with recurrent malignant glioma. Proc Am Soc Clin Oncol 19:160a, 2000.

Handforth A, Ondo WG, Tatter S, Mathern GW, Simpson RK Jr., Walker F, Sutton JP, Hubble JP, Jankovic J. Effect of vagus nerve stimulation on essential tremor. Neurology 54(Suppl 3):A238, 2000.

Tatter SB, Carlos RA, O'Donovan CA. Intraparenchymal alpha interferon and intraventricular ribavirin for subacute sclerosing panencephalitis (SSPE). Neurology 54(Suppl 3):A430, 2000.

Tatter SB, Namen AM, Ely EW, Lucia MA, Case DL, Landry S, Haponik EF, Glazier SS, Wilson JA, Branch CL Jr, MD, Kelly DL Jr. Predictors of Successful Extubation in Neurosurgical Patients. Neurosurgery 47:536, 2000.

Ely EW, Namen AM, Tatter SB, Lucia MA, Smith A, Landry S, Case DL, Haponik EF (1999). Impact of ventilator weaning protocol in Neurosurgical patients. A randomized controlled trial. Am J Respir Crit Care Med 159: 370A

Tatter SB (1999). Neurosurgical management of brain tumors. In Neuroimaging Clinics of North America, Peter E. Ricci, M.D., editor, W.B. Saunders Company, 9:779-800.

Olivi A, Barker F, Tatter S, Bruce J, Judy K, Engelhard H, Burak E, Hilt D, Grossman S, Fisher JD, Piantadosi S for the NABTT CNS Consortium and Guilford Pharmaceuticals, Inc (1999). Toxicity and pharmacokinetics of interstitial BCNU administered via wafers. Results of a phase I study with recurrent malignant glioma. Proc Am Soc Clin Oncol 18:543.

Olivi A, Barker F, Tatter S, Bruce J, Judy K, Engelhard H, Burak E, Hilt D, Grossman S, Fisher JD, Piantadosi S for the NABTT CNS Consortium and Guilford Pharmaceuticals, Inc (1999). Results of a phase I study of interstitial BCNU administered via wafers to patients with recurrent malignant glioma. Neuro-Oncology 1:329.

Eskey CJ, Lev MH, Tatter SB (1998). Cerebral CT venography in surgical planning for a tentorial meningioma. Journal of Computer Assisted Tomography. 22:530-2.

Tatter SB, Harsh GR IV. (1997) Current treatment modalities for brain tumors. In Chiocca and Breakefiled, eds. Gene Therapy for Neurologic Diseases Humana, 157-185.

Tatter SB, Butler WE, Chapman PH. (1997) Technical and clinical aspects of proton-beam radiosurgery. In Gildenberg and Tasker, eds. Stereotactic Neurosurgery McGraw-Hill, 80-1--80-6.

Galpern WR, Tatter SB, Isacson O (1997). Neurotrophic factor protection in models of neurodegeneration. Implications for the treatment of neurodegenerative disorders. In Beal MF, Howell N, Bodis-Wollner I, eds. Mitochondria and Free Radicals in Neurodegenerative Diseases. Wiley-Liss, New York, pp 557-583.

Tatter SB, Hopkins JW (1997). Cerebral manifestations of Ascaris lumbricoides. J Contemp Neurol, 1997:2-5.

Tatter SB, Ojemann RG (1997). Surgical management of hemangioblastoma in von Hippel-Lindau disease. . [oral presentation SB Tatter] 1997 VHL Family Alliance/National Institutes of Health Conference on von Hippel-Lindau Disease, Bethesda, MD, p. 9.

Tatter SB, Barker FG II, Ojemann RG (1996). Hemangioblastoma. Von Hippel-Lindau disease and sporadic. [oral presentation SB Tatter] New England Neurosurgical Society: Annual Meeting, Boston, MA p. 4.

Spangler WJ, Frim DM, Tatter SB, Barker FG II, Cosgrove GR (1996). Clinical impact of stereotactic brain biopsy. A retrospective review of 484 cases. J Neurosurg 84:350A-351A.

Galpern WR, Frim DM, Tatter SB, Altar CA, Beal MF, Isacson O (1996). Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels. Cell Transplantation 5:225-232.

Tatter SB, Galpern WR, Isacson O (1995). Neurotrophic factor protection against excitotoxic neuronal death. The Neuroscientist, 1:286-297.

Tatter SB, Wilson CB, Harsh GR IV. (1995) Neuroepithelial tumors of the adult brain. In Youmans JR, ed. Neurological Surgery, Fourth Edition, Vol. 4: Tumors. W.B. Saunders Co., Philadelphia, pp. 2612-2684.

Tatter SB, Crowell RM, Ogilvy CS (1995). Aneurysmal and microaneurysmal 'angiogram-negative' subarachnoid hemorrhage. Neurosurgery 37:48-55.

Tatter SB, Crowell RM, Ogilvy CS (1995). Acute lacunar stroke in association with angiogram-negative subarachnoid hemorrhage. Mechanistic implications of two cases. Stroke 26:891-5.

Tatter SB, Galpern WR, Hoogeveen AT, Isacson O (1995). Effects of striatal excitotoxicity on huntingtin-like immunoreactivity. Neuroreport 6:1125-9.

Tatter SB, Edgar MA, Klibanski A, Swearingen B (1995). Symptomatic salivary-rest cyst of the sella turcica [pituitary]. Acta Neurochir (Wein), 135:150-3.

Tatter SB, Ogilvy CS (1995). Vascular malformations. General considerations. In Ojemann RG, Ogilvy CS, Crowell RM, Heros RC, eds. Surgical Management of Cerebrovascular Disease, Third edition. Williams & Wilkins, Baltimore, 387-403.

Tatter SB, Ogilvy CS, Golden JA, Ojemann RG, Louis DN (1994). Third ventricular xanthogranulomas clinically and radiologically mimicking colloid cysts. Report of two cases. J Neurosurgery 81:605-9.

Tatter SB, Cosgrove GR, (1994). Hemorrhage into a lumbar synovial cyst causing an acute cauda equina syndrome. Case report. J Neurosurgery 81:449-52.

Barker F, Tatter SB (1994). Flow directed placement of a ventriculo-atrial shunt. Technical report. Neurosurgery 35:534-6.

Tatter SB, Borges LF, Louis DN (1994). Central neurocytomas of the cervical spinal cord. Report of two cases. J Neurosurgery 81:288-93.

Tatter SB, Borges LF, Louis DN (1995). Recurrent central neurocytoma of the spinal cord (letter). J Neurosurgery 82:184.

DiSalvo TG, Tatter SB, O'Gara PT, Neilson GP, DeSanctis RW (1994). Fatal intracerebral hemorrhage following thrombolytic therapy of embolic myocardial infarction in unsuspected infective endocarditis. Clin Cardiol 17:340-4.

Ogilvy CS, Tatter SB (1995). Tumors, aneurysms, and vascular malformations during pregnancy. In Schmidek HH, Sweet WH, eds. Operative Neurosurgical Techniques: Indications, Methods and Results, Fourth Edition. W.B. Saunders Co., Philadelphia, pp. 387-403.

Tatter SB, (1990). Interleukin 6: Mediator of the Acute Phase Reaction, Rockefeller University Ph.D. Dissertation, New York, NY.

Bhardwaj N, Santhanam U, Lau LL, Tatter SB, Ghrayeb J, Rivelis M, Steinman RM, Sehgal PB, May LT, (1989). Interleukin-6/interferon-beta2 in synovial effusions of patients with rheumatoid arthritis and other arthritides. Identification of several isoforms and studies of cellular sources. J Immunol 143: 2153-2159.

May LT, Torcia G, Cozzolino F, Ray A, Tatter SB, Santhanam U, Sehgal PB, Stern D, (1989). Interleukin-6 gene expression in human endothelial cells. RNA start sites, multiple IL-6 proteins, and inhibition of proliferation. Biochem Biophys Res Comm 159:991-998.

Ray A, Tatter SB, Santhanam U, Helfgott DC, May LT, Sehgal PB, (1989). Regulation of expression of interleukin-6. Molecular and clinical studies. In PB Sehgal, G Grieninger, and G Tosato, eds. Regulation of the Acute Phase and Immune Responses: Interleukin-6 [Ann N Y Acad Sci 557:] 353-362.

May LT, Santhanam U, Tatter SB, Ghrayeb J, Sehgal PB, (1989). Multiple forms of human interleukin-6. Phosphoglycoproteins secreted by many different tissues. In PB Sehgal, G Grieninger, and G Tosato, eds. Regulation of the Acute Phase and Immune Responses: Interleukin-6 [Ann N Y Acad Sci 557:] 114-119.

Helfgott DC, Tatter SB, Santhanam U, Clarick RH, Bhardwaj N, May LT, Sehgal PB, (1989). beta2-Interferon / interleukin-6 in plasma and body fluids during acute bacterial infection. J Immunol 142: 948-953.

Fong Y, Moldawer LL, Marano M, Wei H, Tatter SB, Clarick RH, Sanathanam U, Sherris D, May LT, Sehgal PB, Lowry SF, (1989). Endotoxemia elicits increased circulating beta2-interferon / interleukin-6 in man. J Immunol 142: 2321-2324.

Tatter SB, Santhanam U, Helfgott DC, May LT, Sehgal PB, (1989). Interferon beta2: Clinical Studies. In Y Kawade and S Kobayashi, eds. Biology of the Interferon System, Proceedings of an International Conference, Kyoto, 1988 (International Society for Interferon Research), pp. 375-380.

Ray A, Tatter SB, May LT, Sehgal PB, (1989). Transcriptional activation of the IFN-beta2 promoter by multiple agents. In Y Kawade and S Kobayashi, eds. Biology of the Interferon System, Proceedings of an International Conference, Kyoto, 1988 (International Society for Interferon Research), pp. 39-44.

Tatter SB, Santhanam U, Ray A, Helfgott DC, Ghrayeb J, May LT, Sehgal PB, (1989). Interferon-beta2 / B-cell differentiation factor BSF-2 / hepatocyte stimulating factor. In H Moses, P Lengyel, and C Stiles, eds., Growth Inhibitory and Cytotoxic Polypeptides , (Alan R. Liss, New York), pp.189-202.

Ray A, Tatter SB, May LT, Sehgal PB, (1988). Activation of the human "beta2-interferon / hepatocyte stimulating factor / interleukin-6" promoter by cytokines, viruses, and second messenger agonists. Proc Natl Acad Sci (USA) 85: 6701-6705.

May LT, Santhanam U, Tatter SB, Bhardwaj N, Ghrayeb J, Sehgal PB, (1988). Phosphorylation of secreted forms of human beta2-interferon / hepatocyte stimulating factor / interleukin-6. Biochem Biophys Res Comm 152: 1144-1150.

May LT, Ghrayeb J, Santhanam U, Tatter SB, Sthoeger Z, Helfgott DC, Chiorazzi N, Grieninger G, Sehgal PB (1988). Synthesis and secretion of multiple forms of "beta2 interferon / B-cell differentiation factor BSF-2 / hepatocyte stimulating factor" by human fibroblasts and monocytes. J Biol Chem 263: 7760-7766.

Sehgal PB, Helfgott DC, Santhanam U, Tatter SB, Clarick RH, Ghrayeb J, May LT (1988). Regulation of the acute phase and immune responses in viral disease. Enhanced expression of the "beta2-interferon/ hepatocyte stimulating factor/ interleukin-6" gene in virus-infected human fibroblasts. J Exp Med 167: 1951-1956.

Santhanam U, Tatter SB, Helfgott DC, Ray A, Ghrayeb J, May LT, Sehgal PB (1988). Structure, genetics, and function of human "beta2-interferon/ B-cell stimulatory factor-2/ hepatocyte stimulating factor" (interleukin-6). In Powanda MC, Oppenheim JJ, Kluger MJ, and Dinarello CA, eds., Monokines and Other Non-lymphocytic Cytokines(Alan R. Liss, New York), pp. 29-34. [Progress in Leukocyte Biology 8: 29-34.]

May LT, Santhanam U, Tatter SB, Ghrayeb J, Sehgal PB (1988). beta2-interferon / B-cell differentiation factor BSF-2 / hepatocyte stimulating factor. A major mediator of the `acute phase response'. In Bonavida B, Gifford GE, Kirchner H, Old LJ, eds, Tumor Necrosis Factor/Cachectin and Related Cytokines, International Conference, Heidelberg, 1987, (S. Karger, Basel), pp. 259-265.

Schatz RA, Wilens TE, Tatter SB, Gregor P, Sellinger OZ (1983). Possible role of increased brain methylation in methionine sulfoximine epileptogenesis. Effects of administration of adenosine and homocysteine thiolactone. J Neurosci Res 10: 437-447.

Porta R, Schatz RA, Tatter SB, Sellinger OZ (1983). The biosynthesis of polyamines in mouse brain. Effects of methionine sulfoximine and adenosylhomocysteine. J Neurochem 40: 836-841.

Schatz RA, Wilens TE, Tatter SB, Sellinger OZ (1982). Hypermethylation in the MSO-epileptogenic brain Reversal by dilantin and phenobarbital. In R.T. Borchardt, E. Usdin, and C. Creveling, eds., The Biochemistry of S-Adenosylmethioine and Related Compounds (Macmillan, London), pp. 675-679.

Porta R, Doyle RL, Tatter SB, Wilens TE, Schatz RA, Sellinger OZ (1981). The biosynthesis of polyamines in the brain of audiogenic seizure-susceptible and -resistant deermice. J Neurochem 37: 723-729.



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