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Funded Research |
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Claude D. Pepper Older Americans Independence Centers (NIH-NIA) |
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PI: Steve Kritchevsky, PhD |
10/01/02 - 9/30/07 |
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Our mission is to assess the risk factors of physical disability in older adults, develop and test effective prevention therapies, and train new investigators in research on aging disability, while developing their leadership qualities. |
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Interventions and Independence for Elders (LIFE) (NIH-NIA) |
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PI: Steve Kritchevsky, PhD |
09/30/01 – 12/2005 |
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This is a single-blind RCT involving comparison of a physical exercise program of moderate intensity with a health education control. |
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Assessment of body composition, CVD risk, and physical performance one-year after completion of a weight loss program (NIH-NIA) |
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PI: Mary Lyles, MD |
7/1/03-6/30/07 |
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The goal of this study is to assess the amount of weight regain and subsequent changes in body composition following a 5-month weight loss program in older women. Assessment of body composition, physical activity and food intake, fasting lipoprotein lipids, glucose, and insulin, blood pressure, and physical performance, including walking distance, grip and knee extensor strength, and self-reported physical function are measured at 6- and 12-months after the completion of weight loss. |
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Diet, Exercise and Metabolism in Older Women (DEMO) (NIA/NIH) |
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PI: Barbara Nicklas, PhD |
2002-2007 |
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The goal of this study is to determine the cellular mechanisms by which AEX intensity affects the loss of abdominal (both subcutaneous and visceral) adipose tissue under conditions of equal energy deficit in postmenopausal women with abdominal obesity. |
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Dietary Protein and Body Comoposition in Older Women (Promo) (NIH/NIA) |
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PI: Steve Kritchevsky, PhD |
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This study will allow researchers to gather preliminary data in support of their hypothesis of energy and/or protein malnutrition in a contributing factor to age-related loss of muscle mass and subsequent loss of physical function, and to calculate accurate sample sizes for the design of a larger randomized controlled clinical trial in older persons. |
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Pepper Older Americans Independence Center
Geriatric Research Center |
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Effects of caloric restriction on physical performance in aged rats: role of cytokine expression and release from visceral adipose tissue (NIH/NIA) |
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PI: Tongjian You, PhD |
07/08/04-07/07/05 |
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The goal of the study is to investigate the association between physical performance and body composition, visceral fat weight, and visceral fat cytokine production, and determine the mechanisms by which caloric restriction attenuates age-related decline in physical performance in male rats. |
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Multi-Ethnic Study of Areteriosclerosis (NIH/NIA) |
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PI: Jingzhong Ding, PhD |
07/01/05-06/01/06 |
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This is an ancillary study of Multi-Ethnic Study of Arteriosclerosis (MESA) and will examine the association of pericardial fat measured by CT with subclinical (calcified coronary plaque measured by CT and left ventricular dysfunction measured by MRI) and clinical measures of coronary heart disease and congestive heart failure in 40 women, frequency-matched by age and race and will be selected from Wake Forest study site. The volume of pericardial fat will be measured using existing CT scans at baseline and follow-ups. This study will be carried out to develop a method for measuring pericardial fat on CT scans and to explore the association of pericardial fat and left ventricular dysfunction. This project will enhance our institution’s expertise in measurement of pericardial fat. |
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Cardiovascular Health Study Functional Aging Ancillary Study- CHS All Stars (NIH/NIA) |
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PI- Stephen Kritchevsky, PhD |
visits 4-2005 to 4-2006 then phone calls for 3 more years |
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The CHS-Allstars Study seeks to identify physiologic markers of exceptional aging. Participants are surviving members of the Cardiovascular Health Study. Participants will be evaluated for functional health. Archived samples of participants who have survived with low levels of functional impairment will be compared to those from persons who developed severe disability. |
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The Epidemiology of Gender, Stress, and the Metabolic Syndrome (NIH/NHLBI) |
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PI: Barb Nicklas,PhD |
9/1/03-8/31/08 |
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The major goal of this study is to examine the effect of psychosocial stress, as indicated by depressive symptoms and stressful social circumstances, on the onset and sequelae of the metabolic syndrome in the elderly. Secondary objectives are to examine underlying biological mechanisms in the effect of psychosocial stress on the metabolic syndrome. Existing data and stored blood samples from two longitudinal community-based studies among older persons: the Health Aging and Body Composition study (n=3,075, mean age=74) and the InChianti study (n=1,456, mean age=69) will be used. |
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