OAIC Completed Study Arthritis, Diet and Activity Promotion Trial (ADAPT)
(1997-2002)ADAPT is a controlled clinical trial to determine whether long-term exercise and dietary weight loss are more effective, either separately or in combination, in improving physical function and physical disability, mobility, pain, and stiffness in older overweight and obese adults with knee osteoarthritis. The study was successfully completed in January, 2001 by enrolling and following for 18 months 316 participants.
The manuscript of the main results in ADAPT and a secondary analysis manuscript have been submitted for publication. Three additional manuscripts are in preparation. An NIA-funded R01 grant has been awarded to perform genetic studies and extend the follow-up of ADAPT participants. (PI Marco Pahor, Title: Gene polymorphisms and prevention of disability) This study is proposed for OAIC support. Another R01 grant is in preparation to test the effects of the ADAPT interventions in larger samples of the population screened, according to function measures not limited to osteoarthritis of the knee. The fifth year of the current OAIC cycle funding is being dedicated to secondary analyses in ADAPT and analyses of biological samples for markers of cartilage degradation and inflammation (Dr. Richard Loeser and Dr. Barbara Nicklas).
The results of this study will provide a unique opportunity to - determine if biomarkers represent valid surrogates of disease activity and
- provide insight regarding effects of exercise and weight loss on systemic cytokine levels.
Five papers on ADAPT are under review and two are in preparation.
Publications under Review from ADAPT: | - Messier, S., Williamson, J., Miller, G. D., Morgan, T., Rejeski, W. J., Sevick, M. A. , Loeser, R., Ettinger, W., and Pahor, M. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the arthritis, diet and activity promotion trial (ADAPT).
- Miller, G. D., Rejeski, W. J., Williamson, J. D., Morgan, T., Sevick, M. A., Ettinger, W. H., and Messier, S. P. The arthritis, diet and activity promotion trial: design, rationale, and baseline results.
- Miller, G. D., Nesbitt, B. A., Rejeski, W. J., Morgan, T., and Messier, S. P. The association between dietary quality and physical function in older adults with knee.
- Miller, G. D., Nesbitt, B. A., Austin, G., and Messier, S. P. The effect of a weight loss intervention on changes in dietary quality in older adults.
- Rejeski, W. J., Focht, B. C., Messier, S., Morgan, T., Pahor, M., and Penninx, B. W. Dietary weight loss and exercise are important behaviors in enhancing the health-related quality of life of overweight and obese older adults with osteoarthritis.
| Publications in Preparation from ADAPT: | - Abbas, H., Penninx, B. W., Messier, S. P., Williamson, J., Nicklas, B., Ambrosius, W., and Pahor, M. Do IL-6 and CRP levels predict change in physical function and disease progression among older adults with knee osteoarthritis?
- Miller, G. D., Nesbitt, B. A., Rejeski, W. J., Morgan, T., and Messier, S. P. The influence of self-monitoring dietary intake and session attendance on weight loss in older adults.
- Nicklas, B., Ambrosius, W., Messier, S. P., Williamson, J., Mychaleckyj, J. C., and Pahor, M. Change in inflammation marker levels after a dietary weight loss and an exercise intervention.
- Rejeski, W. J., Focht, B. C., Morgan, T., and Messier, S. P. Dose-response effect of exercise intervention on pain and physical function outcome.
- Van Gool, C. H., Penninx, B. W., Kempen, G. I. J. M., van Eijk, J. T., Rejeski, W. J., and Pahor, M. The influence of depression on the compliance to life style interventions.
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