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John S. Parks, Ph.D.

John S. Parks, Ph.D.

Professor, Lipid Sciences
Contact Information
Office:
336-716-2145
Fax:
3367166279
Education & Training
DegreeOrganizationIssued
  BSNorth Carolina State University1973
  MSWake Forest University1976
  PhDWake Forest University1979
Memberships
Sigma Xi Society
Aha - Council On Arteriosclerosis
John S. Parks, Ph.D.

John S. Parks, Ph.D.

Professor, Lipid Sciences
Contact Information
Office:
336-716-2145
Fax:
3367166279
Research Interests
animals, cells/membranes/tissu, atherosclerosis/thrombosis, nutrition, biological/chemical compounds, cardiovascular system, education/training (all f, t,, basic mechanisms, transgenics, animals, whole, immunology/allergy/inflammatio, obesity, diabetes, molecular biology/molecular me, lymphatic & reticulo-endotheli, vascular diseases
Recent Publications
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR, Immunity, 10/21/2009

Macrophage ABCA1 functions as an inhibitor of inflammation through modulation of cellular free cholesterol content [abstract], Arterioscler Thromb Vasc Biol, 10/12/2009

High polyunsaturated fatty acid diet unmasks role of 12/15 lipoxygenase in lipid metabolism [abstract], Arterioscler Thromb Vasc Biol, 10/08/2009

ApoM expression causes formation of larger nascent HDL particles and preferential cholesterol efflux from late endosomes by ABCA1 [abstract], Arterioscler Thromb Vasc Biol, 10/08/2009

Defective vesicle trafficking is associated with increased VLDL triglyceride secretion in hepatocyte-specific ABCA1 knockout mice [abstract], Arterioscler Thromb Vasc Biol, 10/07/2009

Targeted deletion of hepatocyte ABCA1 induces futile cycling of VLDL production and clearance in C57BL/6 mice [abstract], Arterioscler Thromb Vasc Biol, 10/06/2009

Echium oil supplementation attenuates atherosclerosis in B100-LDLrK0 mice [abstract], Arterioscler Thromb Vasc Biol, 10/06/2009

Echium oil promotes phenotypic shifting in the macrophage lineage [abstract], Arterioscler Thromb Vasc Biol, 10/05/2009

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins, J Lipid Res, 06/19/2009

Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function, J Neurosci, 05/13/2009

A novel role for Abca1-generated large nascent HDL in the regulation of VLDL triglyceride secretion [abstract], Circulation, 04/20/2009

Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons, Am J Physiol Cell Physiol, 04/20/2009

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis, Arterioscler Thromb Vasc Biol, 04/17/2009

Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL, J Lipid Res, 01/29/2009

Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-only LDL receptor knockout mice, J Nutr Biochem, 01/07/2009

Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages, J Biol Chem, 12/04/2008

Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis, Circulation, 11/18/2008

LXR signaling couples sterol metabolism to proliferation in the acquired immune response, Cell, 11/04/2008

Macrophage ABCA1 dampens inflammation by modulation of free cholesterol distribution in membrane lipid rafts [abstract], Arterioscler Thromb Vasc Biol, 07/30/2008

Mice lacking ABCA1 and ACAT2 have surface-rich, core-depleted LDL due to LCAT deficiency [abstract], Arterioscler Thromb Vasc Biol, 07/29/2008

Mainstream tobacco smoke inhalation exposure induces time- and dose-dependent increases for aortic cholesterol content within ApoE-/-knockout mice maintained on an atherogenic diet [abstract], Arterioscler Thromb Vasc Biol, 07/22/2008

Inhibition of stearoyl-CoA desaturase 1 (SCD1) dissociates insulin resistance and obesity from atherosclerosis [abstract], Arterioscler Thromb Vasc Biol, 07/21/2008

Hepatic-specific deletion of ABCA1 promotes PI3 kinase-dependent VLDL maturation: a novel role for ABCA1 in the regulation of VLDL triglyceride assembly [abstract], Arterioscler Thromb Vasc Biol, 07/21/2008

Mechanisms by which botanical lipids affect inflammatory disorders, Am J Clin Nutr, 03/28/2008

The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction, Nat Struct Mol Biol, 12/10/2007

Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1, Arterioscler Thromb Vasc Biol, 10/11/2007

Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice, J Lipid Res, 08/09/2007

The effect of selective inactivation of macrophage ATP binding cassette transporter al (ABCA1) on atherosclerosis in LDL-receptor knockout (LDLrK0) mice [abstract], Arterioscler Thromb Vasc Biol, 08/08/2007

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment, Nat Med, 06/27/2007

Histone deacetylase inhibitors decrease macrophage foam cell formation and stabilize atherosclerotic plaques by multiple mechanisms [abstract], Arthritis Rheum, 03/27/2007

Initial interaction of lipid free apoA-I with ATP binding cassette transporter at impacts metabolic fate of apoA-I in vivo [abstract], Circulation, 02/01/2007

Selective deficiency of hepatic ABCA1 results in increased susceptibility to atherosclerosis [abstract], Circulation, 01/30/2007

Hepatic ABCA1 is a key molecule in HDL cholesteryl ester metabolism in mice [abstract], Atheroscler Suppl, 01/24/2007

Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo, Circulation, 12/13/2006

Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels, Circ Res, 11/08/2006

Reduction in ABCG1 in type 2 diabetic mice increases macrophage foam cell formation, J Biol Chem, 11/01/2006

Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice, Arterioscler Thromb Vasc Biol, 10/12/2006
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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