Title: Diabetes Prevention Program Outcome Study (DPPOS)
WFUSM Principal Investigator: Charles H. Tegeler, M.D.
Purpose: The Diabetes Prevention Program (DPP) was a multi-center trial examining the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population due to the presence of impaired glucose tolerance (IGT). The DPP has ended early demonstrating that lifestyle reduced diabetes onset by 58% and metformin reduced diabetes onset by 31%. The DPPOS is designed to take advantage of the scientifically and clinically valuable DPP participants. This group of participants is nearly 50% minority and represents the largest IGT population ever studied. Clinically important research questions remain that focus on 1) durability of the prior DPP intervention, 2) determination of the clinical course of precisely known new onset diabetes, in particular regarding cardiovascular disease (CVD), CVD risk factors and atherosclerosis and microvascular disease, 3) close examination of these topics in men vs. women and in minority populations.
B-Mode Ultrasound Center Role: Carotid Ultrasound Reading Center
WFUSM Work Completed: January 2007
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Prime Award No. 5-U01-DK048489-13 with The George Washington University
Closed to Enrollment