Martin K. Childers, D.O., Ph. D.
Associate Professor
Clinical Interests: Rehabilitation Research emphasis: Physiological and molecular analysis of protein deficiencies in skeletal muscle that lead to muscular dystrophies.
Interium Director, Rehabilitation
EDUCATION:
1980 B. A., Seattle Pacific University, Seattle, Washington
1990 D.O. Western University, College of Osteopathic
Medicine of the Pacific, Pomona, California
POST DOCTORAL TRAINING:
2002 Ph.D., University of Missouri-Columbia, School of
Medicine, Department of Physiology,
Columbia, Missouri
PROFESSIONAL LICENSURE:
2006 – current North Carolina
1991 – current Missouri
SPECIALTY CERTIFICATION:
2005 American Academy of Physical Medicine &
Rehabilitation
Dr. Childers is interested in role of skeletal muscle proteins, and how they interact to protect the muscle cell from stretch-induced damage during contraction. This line of research explores the effects of protein deficiencies that cause muscle diseases (muscular dystrophies) in cultured muscle cells, single fiber and in whole muscle functional assays. Methods used in the Childers' lab include targeted gene expression in cultured cells and in vivo transfection of plasmid DNA in mice. The lab also utilizes a canine model of Duchenne muscular dystrophy, termed golden retriever muscular dystrophy (GRMD). The GRMD colony at the University of Missouri is the largest and most successful colony worldwide. This canine model of dystrophin deficiency allows for function assessment of muscle strength and response to pharmacologic agents potentially useful in the treatment of humans with muscular dystrophy. The overall goal of this line of research is to better understand the functional role of muscle cell proteins and how they act to protect the cell during contraction.
BIBLIOGRAPHY:
Books
(* Denotes Corresponding author)
Childers MK (ed): Use of botulinum toxin type A in pain management. Academic Information Systems, Columbia, MO, 1999.
Childers MK (ed): Use of alpha-2 adrenergic agonists in pain management. Academic Information Systems, Columbia, MO, 2001.
Childers MK (ed): Use of botulinum toxin type A in pain management, 2nd Edition. Academic Information Systems, Columbia, MO, 2002.
Book chapters
Gnatz S, Childers MK: Acute Pain. In: Grabois M, Garrison SJ (eds). Physical Medicine and Rehabilitation: The Complete Approach. Blackwell Science, Inc., Cambridge, MA., 2000.
Childers MK, Simons DG: Botulinum toxin use in myofascial pain syndromes. In:Lennard T (ed). Pain Procedures in Clinical Practice, 2nd Edition. Hanley & Belfus, Inc., Philadelphia, PA., 2000.
Kracke GR, Childers MK: Peripheral mechanisms of pain transmission and relief. In:Childers MK (ed). Use of Alpha-2 Adrenergic Agonists in Pain Management. Academic Information Systems, Inc., Columbia, MO., 2001.
Childers MK: How alpha-2 adrenergic agonists relieve pain. In:Childers MK (ed). Use of Alpha-2 Adrenergic Agonists in Pain Management. Academic Information Systems, Inc., Columbia, MO., 2001.
Childers MK: Case studies. In:Lennard T (ed). Physical Medicine and Rehabilitation Pearls. Hanley & Belfus, Inc., Philadelphia, PA, 2001.
Childers MK, Trochanteric Bursitis, In Waldman. In Pain Management (Vol. 1). Saunders Elsevier, Philadephia, PA, 2007
Childers MK, Markert C: Cervical Dystonia. In Waldman. In Pain Management (Vol. 1). Saunders Elsevier, Philadephia, PA, 2007
Childers MK, Markert C: Cervical Dystonia. In Waldman. In Pain Management (Vol. 2). Saunders Elsevier, Philadephia, PA, 2007
Journals
Schafer SJ, Schafer LO, Anglen JO, Childers MK: Heterotopic ossification in rehabilitation patients who have had internal fixation of an acetabular fracture. J Rehabil Res Dev, 37(4):389-393, 2000.
Childers MK, Okamura CS, Bogan DJ, Bogan JR, Sullivan MJ, Kornegay JN: Myofiber injury and regeneration in a canine homologue of Duchenne muscular dystrophy. Am J Phys Med Rehabil 80(3):175-181, 2001.
Childers MK, Doll J, Stenehjem A: Pharmacologic management of myofascial pain syndromes. The New England Pain Association Journal, 7(1):14-23, 2002.
Childers MK, Wilson DJ, Gnatz SM, Conway RR, Sherman AK: Botulinum toxin type A use in piriformis muscle syndrome: A pilot study. Am J Phys Med Rehabil, 81(10):751-759, 2002.
Childers MK*, Okamura CS, Bogan DJ, Bogan JR, Petroski GF, McDonald K, Kornegay JN: Eccentric contraction injury in dystrophic canine muscle. Arch Phys Med Rehabil 83(11):1572-1578, 2002.
Childers MK*: The importance of electromyographic guidance and electrical stimulation for injection of botulinum toxin. (Review). Phys Med Rehabil Clin N Am 14:781-792, 2003.
Childers MK*, McDonald KS: Regulatory light chain phosphorylation increases eccentric contraction-induced injury in skinned fast-twitch fibers. Muscle Nerve 29:313-317, 2004.
Childers MK*, Brashear A, Jozefczyk P, Reding M, Alexander D, Good D, Walcott JM, Jenkins SW, Turkel C, Molloy PT: Dose-dependent response to intramuscular botulinum toxin type A for upper-limb spasticity in patients after a stroke. Arch Phys Med Rehabil 85(7):1063-1069, 2004.
Childers MK*:Targeting the neuromuscular junction in skeletal muscles.
Am J Phys Med Rehabil Oct;83(10 Suppl):S38-44, 2004.
Liu MK, Okamura CS, Bogan DJ, Bogan JR, Childers MK*, Kornegay JN: Effects of prednisone in canine muscular dystrophy. Muscle Nerve Dec;30(6):767-73, 2004.
Childers MK*, Staley JT, Kornegay JN, McDonald KS: Skinned single fibers from normal and dystrophin-deficient dogs incur comparable stretch-induced force deficits Muscle Nerve Jun;31(6):768-71, 2005
Childers MK*, Borenstein D, Brown RL, Gershon S, Hale ME, Petri M, Wan GJ, Laudadio C, Harriosn DD: Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial. Cur Med Res Opin 21(9) 1485-1493, 2005.
Wilson DJ, Powell M, Gorham JL, Childers MK. Ambulation training with and without partial weightbearing after traumatic brain injury: results of a randomized, controlled trial. Am J Phys Med Rehabil 2006; 85:68-74.
Schopp LH, Clark M, Mazurek MO, Hagglund KJ, Acuff ME, Sherman AK, Childers MK. Testosterone levels among men with spinal cord injury admitted to inpatient rehabilitation. Am J Phys Med Rehabil Aug;85(8):678-84, 2006.
Markert C, Childers MK. Myostatin expression in muscular dystrophies and mitochondrial encephalomyopathies. Pediatr Neurol Oct,35:300, 2006.