James F. Toole, M.D.
Professor
EDUCATION:
1938-1943 Shady Side Academy, Pittsburgh, Pennsylvania
1943-1947 B.A., Princeton University, Princeton, New Jersey
1945-1949 M.D., Cornell University Medical College, New York, New York
1963 L.L.B., LaSalle Extension University, Chicago, Illinois
POSTDOCTORAL TRAINING:
1948 Public Health Fellow in Tropical Medicine, Havana, Cuba
1949-1950 Intern, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
1953-1955 Resident in Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
1955-1956 Fulbright Fellow in Neurology, National Hospital, Queen Square, London, England
1956-1958 Resident in Neurology, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
PROFESSIONAL LICENSURE:
1950 Diplomat of National Board of Medical Examiner
1951 Pennsylvania
1957 California
1962 North Carolina
SPECIALTY CERTIFICATION:
1942 American Federation of Labor District Council of Carpenters
1958 American Board of Internal Medicine
1961 American Board of Psychiatry and Neurology
1987 American Society of Neuroimaging – Neurosonology
1992 American Board of Neurorehabilitation
James F. Toole was born in Atlanta, Georgia on March 22, 1925. He received his B.A. degree from Princeton University in 1947, his M.D. degree from Cornell University Medical College in 1949, and his L.L.B. from LaSalle Extension University in 1963. He spent six years in the United States Navy, three of which as a flight surgeon.
From 1948 to 1958, he did his postgraduate training in Havana, Cuba; Philadelphia, Pennsylvania; and the Institute of Neurology, Queen’s Square, London, as a Fulbright Scholar in Neurology.
He has been certified by the American Board of Internal Medicine, American Board of Psychiatry and Neurology, American Society of Neuroimaging – Neurosonology, and the American Board of Neurorehabilitation.
He is the Walter C. Teagle Professor of Neurology and Director of the Cerebrovascular Research Center, dividing his time among academic activities, research, and the training of fellows, house officers, and medical students. He was Chairman of the Department of Neurology from 1962-1983.
He has been a consultant to the World Health Organization meetings in Japan, Switzerland, Africa, and the USSR. His expertise on the nervous system and its disorders has been presented in pamphlets for the American Heart Association and the North Carolina Heart Association; in five editions of his book, Cerebrovascular Disorders; three volumes of The Handbook of Clinical Neurology; in teaching films; on local and national television; and in over 600 published articles. He has served as a member of editorial boards on numerous publications. Research activities include Director and Principal Investigator of the Cerebrovascular Research Center; Principal Investigator of the Asymptomatic Carotid Atherosclerosis Study (ACAS); Co-Principal Investigator of the Atherosclerosis Risk in Communities (ARIC) study; and Principal Investigator of the Vitamins for Intervention in Stroke Prevention (VISP) study.
Dr. Toole has been active in American and international societies and organizations for many years. A small sampling of his involvements include: Secretary-Treasurer and President of the American Neurological Association; an eight year term as Secretary Treasurer General of the World Federation of Neurology; Editor-in-Chief of the Journal of Neurological Sciences; Vice-President and President of the American Society of Neuroimging; President of the World Federation of Neurology; And is now serving a four year term as President of the International Stroke Society.
SELECTED BIBLIOGRAPHY:
Chapters in Books:
Flye M, Toole JF. British and American Neurologists Meet: London, 1927. Twentieth Century Neurology: The British Contribution. London Neurological Centre, UK
Toole JF, Bibileishvili E. Cerebrovascular Events. IN: Ratnaike RN (ed). Practical Guide to Geriatric Medicine. Australia: McGraw-Hill, 2002:225-238.
Bettermann K, Toole JF. Diagnostic evaluation and medical management of patients with ischemic cerebrovascular Disease. In: Rutherford RB, ed. Vascular Surgery. 6th Ed. Philadelphia: Elsevier Saunders. 2005:1897-1916.
Journal Articles:
Toole JF. Stroke Research and the 21st Century. Arch Neurol 2000;57:55.
Veltkamp R, Warner DS, Domoki F. Brinkhous AD, Toole JF, Busija DW. Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Res 2000;853:68-73.
Menken M, Munsat TL, Toole JF. The global burden of disease study. Arch Neurol 2000;57:418-420.
Pettigrew LC, Thomas N, Howard VJ, Veltkamp R, Toole JF, for the Asymptomatic Carotid Atherosclerosis Study Investigators. Low mini-mental status predicts mortality in asymptomatic carotid arterial stenosis. Neurology 2000;55:30-34.
Spence JD, Howard VJ, Chambless LE, Malinow MR, Pettigrew LC, Stampfer M, Toole JF for the VISP Investigators. Vitamin Intervention for Stroke Prevention (VISP) Trial: Rationale and Design. Neuroepidemiology 2001;20:16-25.
Howard VJ, Sides EG, Newman GC, Cohen SN, Howard G, Malinow MR, Toole JF for the Stability of Plasma Homocyst(e)ine in Acute Stroke Patients (SHASP) Study Investigators. Changes in plasma homocyst(e)ine in the acute phase after stroke. Stroke 2002;33:473-478.
Toole JF, Jack CR. Food (and vitamins) for thought. Neurology 2002;58:1449-1450.
Toole JF. Vitamin Intervention for Stroke Prevention. J Neurol Sci 2002;203-204:121-124.
Toole JF, Pennell T. Wake Forest University International Medicine. South Med J 2002;95:1376-1380.
Everson KR, Rosamond WD, Cai, J, Toole JF, Hutchinson RG, Shabar E, Folsom AR. Physical activity and ischemic stroke risk, The Atherosclerosis Risk in Communities Study. Stroke. 199;30:1333-1339.
Elter JR, Offenbacher S, Toole JF, Beck JD: Relationship of periodontal disease and edentulism to stroke/TIA. J Dent Res 2003;82(12): 998-1001
Gebel JM, Brott TG, Howard VJ, Tomsick TA, Sauerback LR, Toole JF: Brain injury as detected by computed tomography (CT) scan in ACAS (abstract). Stroke 2003;34(1):238
Zhang JH, Singhal AB, Toole JF. Oxygen therapy in ischemic stroke (letter) (on-line only). Stroke 2003;34(9):e152-e153
Lutsep HL, Campbell S, Chambless LE, Howard VJ, Malinow MR, Toole JF .Plasma homocyst(e)ine levels in stroke patients screened for the VISP study in the era of folate fortification (abstract) Stroke 2004;35(1):313
Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG (Department of Neurology), Wang C-H, Stampfer M: Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke (VISP) randomized controlled trial. JAMA 2004;291(5):565-575
Chambless LE, Toole JF, Nieto FJ, Rosamond W, Paton C: Association between symptoms reported in a population questionnaire and future ischemic stroke: the ARIC study. Neuroepidemiology 2004;23(1-2):33-37
Toole JF, Bhadelia R, Williamson JD, Veltkamp R: Progressive cognitive impairment after stroke. Journal of Stroke and Cerebrovascular Diseases 2004; 13:3: 99-103
Chambless LE, Heiss G, Shahar E, Earp MJ, Toole JF: Prediction of Ischemic Stroke Risk in the Atherosclerosis Risk in Communites Study. American Journal of Epidemiology 2004;160:259-269
Fisher M, Paganini-Hill A, Martin A, Cosgrove M, Toole JF (Department of Neurology), Barnett HJM, Norris J: Carotid plaque pathology: thrombosis, ulceration, and stroke pathogenesis. Stroke 2005;36(2): 253-257.
Toole JF, Screenings Vital to Reduce Stroke Rate, Visions, Wake Forest University Baptist Medical Center, Spring/Summer 2005
Radziszewska B, Hart R, Wolf P, D’Agostino R, Cutler J, Toole JF (Contributing C-Author). Clinical Research in Primary Stroke Prevention: Needs, Opportunities, and Challenges. Neuroepidemiology 2005;25:91-104.
Fisher M, Paganini-Hill, A, Martin A, Cosgrove M, Toole JF, Barnett H, Norris J. Carotid Plaque Pathology. Stroke. 2005;36:253-257.