David S. Lefkowitz, M.D.
Associate Professor
CLINICAL INTERESTS: Asymptomatic carotid atherosclerosis, acute stroke, migraine, and multiple sclerosis
EDUCATION:
1970-1974 Franklin and Marshall College
Lancaster, Pennsylvania
A.B. (Biology)
Graduated cum laude
1974-1978 Bowman Gray School of Medicine
Winston-Salem, North Carolina
M.D.
POST DOCTORAL TRAINING
1978-1979 Neurology Categorical Internship
North Carolina Baptist Hospital
Winston-Salem, North Carolina
1979-1982 Neurology Residency
North Carolina Baptist Hospital
Winston-Salem, North Carolina
January 1982-May 1982 Chief Resident in Neurology
North Carolina Baptist Hospital
Winston-Salem, North Carolina
July 1982-June 1983 Fellowship in Cerebrovascular Disease
North Carolina Baptist Hospital
Winston-Salem, North Carolina
PROFESSIONAL LICENSURE:
North Carolina
SPECIALTY CERTIFICATION:
1984 – Current Board Certified, American Board of Psychiatry and Neurology
Dr. Lefkowitz completed his undergraduate training at Franklin and Marshall College and attended medical school at the Bowman Gray School of Medicine of Wake Forest University. He completed his internship and Neurology residency at North Carolina Baptist Hospital. He joined the faculty after completing a fellowship in cerebrovascular disease at Bowman Gray School of Medicine in 1983.
Dr. Lefkowitz is a diplomat of the American Board of Psychiatry and Neurology. He is a member of the American Academy of Neurology, the American Neurologic Association and the Stroke Council of the American Stroke Association. His clinical interests are cerebrovascular disease and headache. He has research interests in acute stroke therapies and stroke prevention. He has participated in multiple NIH funded clinical trials including the Asymptomatic Carotid Artery Plaque Study (ACAPS), the Asymptomatic Carotid Atherosclerosis Study (ACAS), and studies of neurologic and neuropsychologic complications of cardiac surgery and falls in the elderly. He is currently an investigator in the Cardiovascular Health Study (CHS), and the Vitamin Intervention for Stroke Prevention Study (VISP) as well as several industry sponsored studies of stroke therapies and immunomodulating treatments for multiple sclerosis.
REPRESENTATIVE PUBLICATIONS
Newman AB, Spiekerman CF, Enright P, Lefkowitz D, Manolio T, Reynolds CF, Robbins, J on behalf of the Cardiovascular Health Study Research Group. Daytime sleepiness predicts mortality and cardiovascular disease in older adults. J Am Geriatr Soc 2000;48:115-123.
Longstreth WT Jr., Diehr P, Manolio TA, Beachamp NJ, Jungreis CA, Lefkowitz D for the Cardiovascular Health Study Collaborative Research Group. Cluster analysis and patterns of findings on cranial MRI of the elderly: the Cardiovascular Health Study. Arch Neurol. 2001;58:635-640.
Reynolds PS, Crenshaw CT, Lefkowitz DS, Shelton BJ, Tegeler CH. A practical stroke severity scale predicts hospital outcomes. J of Stroke and Cerebrovascular Diseases 2001;10:231-235.
Johnston SC, O’Meara ES, Manolio TA, Lefkowitz D, O’Leary DH, Goldstein S, Carlson MC, Fried LP, Longstreth WT Jr: Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. Ann Intern Med 2004; 140:237-247.
Jeffery DR, Lefkowitz DS, Crittenden JP. Treatment of Marburg variant multiple sclerosis with mitoxantrone. J Neuroimaging 2004;14:58-62.
Sloan MA, Alexandrov AV, Tegeler CH, Spencer MP, Caplan LR, Feldmann E, Wechsler LR, Newell DW, Gomez CR, Babikian VL, Lefkowitz D, Goldman RS, Armon C, Hsu CY, Goodin DS; Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Assessment: transcranial Doppler ultrasonography: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2004;62;1468-1481.
Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles M, Lefkowitz D, Sicovick DS. Fish intake and risk of incident atrial fibrillation. Circulation 2004;110:368-373.
Longstreth WT, Arnold A, Beauchamp NJ, Manolio TA, Lefkowitz D, Jungreis C, Hirsch CH, O'Leary DH, Furberg CD. Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly. The Cardiovascular Health Study. Stroke 2005;36:56-61.
Kaplan RC, Tirshwell DL, Longstreth WT Jr, Manolio TA, Heckbert SR, Lefkowitz D, El-Saed A, Psaty BM. Vascular events, mortality, and preventive therapy following ischemic stroke in the elderly. Neurology 2005;65:835-842.
Kaplan RC, Tirshwell DL, Longstreth WT Jr, Manolio TA, Heckbert SR, LeValley, Lefkowitz D, El-Saed A, Psaty BM. Blood pressure level and outcomes in adults aged 65 and older with prior ischemic stroke. J Am Geriatr Soc 2006;54:1309-1316.
Longstreth W Jr., Larsen EK, Klein R, Wong TY, Sharrett AR, Lefkowitz D, Manolio TA. Associations between findings on cranial magnetic imaging and retinal photography in the elderly: The Cardiovascular Health Study. Am J Epidemiol 2007;165:78-84.