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Clinical Trials and Research Grants

The Nephrology faculty is actively involved in several clinical trails.  The term clinical trial may be applied to any form of planned experiment which involves patients and is designed to elucidate the most appropriate treatment of future patients with a given medical condition.

Many thousands of people take part in medical trials every year. When a qualified candidate chooses to participate in a clinical study, the research often affects thousands of others who benefit from the trial's results.

Below is a list of recently completed and current grants in which the Nephrology faculty is involved.

Wyeth Ayerst
A double-blind comparative study of the effect of two dose levels of Sirolimus versus azathioprine, administered concomitantly with standard immuno--suppressive therapy in renal allograft recipients
Principal Investigator: Patricia Adams, M.D.

1996-1999

Sangstat
Controlled, randomized open label multi-center study comparing Sang-35 oral solution with Neoral capsules in de novo adult renal allograft recipients.
Principal Investigator: Patricia Adams, M.D.

1998-2000

National Institutes of Health
“Family Investigation in Nephropathy and Diabetes (FIND)"

Principal Investigator: Barry I. Freedman, M.D.
Co-Investigator:  Scott G. Satko, M.D.

1999-2006

National Institutes of Health,(Subcontract with University of Pittsburgh)
"Genotype and Phenotype of Familial Nephropathy with Gout"
Principal Investigator:Thomas Hart, M.D. (University of Pittsburgh)

Principal Investigator:  Anthony J. Bleyer, M.D.

2002-2006

Genzyme Pharmaceuticals
"A Randomized, Open Label, Parallel Design Study of Sevelamer Hydrochloride (Renagel) in Chronic Kidney Disease Patients"
Principal Investigator:  Anthony J. Bleyer, M.D.

2002-present

National Institutes of Health
PAS (Subcontract with Case Western Reserve University)
"Renal Disease Progression in African Americans"     
Principal Investigator:  Jeffrey Schelling, M.D. (Case Western Reserve University)
Principal Investigator:  Anthony J. Bleyer, M.D.
Co‑Investigator:  Barry I. Freedman, M.D.
Co-Investigator: John M. Burkart, M.D.

2002-2008

National Institutes of Health
“Genetics of African American Type 2 Diabetes”
Principal Investigator:  Michele Sale, Ph.D.
Co-Investigator:  Barry I. Freedman, M.D.

2003-2007

National Institutes of Health/VA
"Intensive versus Conventional Renal Support in Acute Renal Failure"
Principal Investigator: Michael V. Rocco, M.D.

2003-2007

Southeastern Kidney Council, Inc.
“Family History of ESRD Prevention Project”
Principal Investigator:  Scott Satko, M.D.
Co-Investigator:  Barry I. Freedman, M.D.

2003-present

National Institutes of Health
"Frequent Hemodialysis Clinical Trial" (Nocturnal HD)
Principal Investigator for the nocturnal clinical coordinating center: Michael V. Rocco, M.D.
Co-Investigator: John M. Burkart, M.D.

2003-2009

National Institutes of Health
"Dialysis Access Consortium” - Clinical center
Principal Investigator:  Michael V. Rocco, M.D.
Co-investigator:  Pirouz Daeihagh, M.D.

2004-2007

National Institutes of Health
"Identification of Diabetes Genes on Human Chromosome 20"
Principal Investigator: Donald Bowden, Ph.D.
Co‑Investigator:  Barry I. Freedman, M.D.

2005-2010

National Institutes of Health
Subclinical CVD in African American type 2 diabetes”
Principal Investigator:  Barry Freedman, M.D.

2005-2010

Keryx Biopharmaceuticals Inc.
The effect of sulodexide in patients with type 2 diabetes and microalbuminuria
Co-investigator:  Pirouz Daeihagh, M.D

2006

Isotechnika Research
“A Phase IIB, randomized, multicenter, open-label, concentration-controlled, safety study of ISA247 and tacrolimus in de novo renal transplant patients”  (PROMISE Trial: Protocol ISA05-01)
Site Principal Investigator:     Erica Hartmann, M.D.

2006-present

Rhubarb and Angiotensin Converting Enzyme Inhibitor Study (RACE) II
Principal Investigator: John Burkhard, M.D.

2006-present

Roche Research
“A Randomized, Double-Blind, Placebo Controlled Multi-Center Study of the Efficacy and Safety of up to 100 days of Valganciclovir versus up to 200 days of Valganciclovir for Prevention of Cytomegalovirus Disease in High-Risk Kidney Allograft Recipients” (IMPACT Trial: Protocol NT18435)
Site Principal Investigator:     Erica Hartmann, M.D.

2006-present

Treatment Resistant Heart Failure and Peritoneal Ultrafiltration
Principal Investigator: John Burkhart, M.D.

2006-present

American Society of Nephrology and Association of Subspecialty Professors 
Junior Development Grant in Geriatric Nephrology
Principal Investigator: Erica Hartmann, M.D.

2006-2008

National Institutes of Health
“Genetic Analysis of African American Hypertensive End-Stage Renal Disease”
Principal Investigator:  Barry I. Freedman, M.D.

2006-2010

Role of blood pressure changes on residual renal function in patients on automated peritoneal dialysis.
Principal Investigator:  Pirouz Daeihagh, M.D.

2007- present

 

 

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Last Modified: 9/28/2007