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Comparative Medicine
Dr. Randolph Geary

Randolph L. Geary, MD FACS

Professor of Pathology (Comparative Medicine) and Surgical Sciences (General Surgery); Institute for Regenerative Medicine
Tel: (336) 716-3188
Fax: (336) 716-9758
rgeary@wfubmc.edu

  • Brooks Scholar in Academic Medicine (General Surgery)
  • Director, Vascular Biology Laboratory (General Surgery)
  • Board Certification: FACS
Education:
  • Undergraduate: University of Idaho, BS cum laude, 1982
  • Postgraduate: University of Washington School of Medicine, MD, 1986
  • Residency: University of Washington School of Medicine, 1986-91
  • Fellowship: University of Washington School of Medicine, 1991-93
  • Residency: University of Washington, Vascular Surgery, 1993-94
Interests:
  • Teaching: Vascular Biology, Vascular Diseases
  • Research: Artery Wall Remodeling in Response to Atherosclerosis and Arterial Injury, Restenosis Following Vascular Reconstruction, Functional Genomics in Artery Wall Biology
  • Clinical: Carotid and Aortic Surgery, General Vascular Surgery
Current Research: Artery Wall Remodeling and Restenosis 

Current research focuses on mechanisms of recurrent lumen narrowing at sites of arterial reconstruction (restenosis) and gene expression profiling in smooth muscle cell populations within normal and diseased human and nonhuman primate arteries. To this end, we have recently characterized the response to angioplasty and intra-arterial stenting in a unique nonhuman primate model of atherosclerosis. Current studies are focused on the correlation between changes in artery wall geometry and lumen narrowing after angioplasty. The importance of cell-matrix adhesive interactions in restenosis is being addressed in experiments using inhibitors of cell-surface integrins and non-integrin receptors for extra-cellular matrix components and inhibitors of matrix degrading metalloproteinases (MMP). Human cDNA arrays have been employed to define profiles of expression in monkey tissues with success. Systematic characterization of smooth muscle cell phenotype in normal and diseased vessels of primates is being applied to experiments of artery wall remodeling.

Recent Publications:

Journal Articles:

Corriere MA, Sauve KJ, Ayerdi J, Craven BL, Stafford JM, Geary RL, Edwards MS.  Vena cava filters and inferior vena cava thrombosis. J Vasc Surg. 2007 Apr;45(4):789-94.

Piercy KT, Ayerdi J, Geary RL, Hansen KJ, Edwards MS. Acute pancreatitis: A complication associated with rheolytic mechanical thrombectomy of deep venous thrombosis. J Vasc Surg. 2006 Nov;44(5):1110-3.

Edwards MS, Craven BL, Stafford J, Craven TE, Sauve KJ, Ayerdi J, Geary RL, Hansen KJ. Distal embolic protection during renal artery angioplasty and stenting.  J Vasc Surg. 2006 Jul;44(1):128-35. 

Adams LD, Geary RL, Li J, Rossini A, Schwartz SM. Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap. Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):319-25.

Igase M, Strawn WB, Gallagher PE, Geary RL, Ferrario CM. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in aorta of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2005 Apr 15; [Epub ahead of print]

English WP, Pearce JD, Craven TE, Edwards MS, Geary RL, Plonk GW, Hansen KJ. Chronic visceral ischemia: symptom-free survival after open surgical repair. Vasc Endovascular Surg. 2004 Nov-Dec;38(6):493-503.

Li J, Adams LD, Wang X, Pabon L, Schwartz SM, Sane DC, Geary RL. Regulator of G protein signaling 5 marks peripheral arterial smooth muscle cells and is downregulated in atherosclerotic plaque. J Vasc Surg. 2004 Sep;40(3):519-28.

Bergt C, Pennathur S, Fu X, Byun J, O'Brien K, McDonald TO, Singh P, Anantharamaiah GM, Chait A, Brunzell J, Geary RL, Oram JF, Heinecke JW. The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13032-7.

Pennathur S, Bergt C, Shao B, Byun J, Kassim SY, Singh P, Green PS, McDonald TO, Brunzell J, Chait A, Oram JF, O'Brien K, Geary RL, Heinecke JW. Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species. J Biol Chem. 2004 Oct 8;279(41):42977-42983.

English WP, Pearce JD, Craven TE, Wilson DB, Edwards MS, Ayerdi J, Geary RL, Dean RH, Hansen KJ. Surgical management of renal artery aneurysms. J Vasc Surg. 2004 Jul;40(1):53-60.

Pearce JD, Li J, Edwards MS, English WP, Geary RL. Differential effects of Rho-kinase inhibition on artery wall mass and remodeling. J Vasc Surg. 2004 Jan; 39(1): 223-8.

Raval GN, Bharadwaj S, Levine EA, Willingham MC, Geary RL, Kute T, Prasad GL. Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors. Oncogene. 2003 Sep 18;22(40):6194-203.

Schwartz SM, Geary RL, Adams LD. Vascular failure: a hypothesis. Curr Atheroscler Rep. 2003 May;5(3):201-7. Review.

Edwards MS, Cherr GS, Craven TE, Olsen AW, Plonk GW, Geary RL, Ligush JL, Hansen KJ. Acute occlusive mesenteric ischemia: surgical management and outcomes. Ann Vasc Surg. 2003 Feb;17(1):72-9.

Geary RL, Wong JM, Rossini A, Schwartz SM, Adams LD. Expression profiling identifies 147 genes contributing to a unique primate neointimal smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):2010-6.

Cherr GS, Edwards MS, Craven TE, Levy PJ, Ligush J Jr, Geary RL, Plonk GW Jr, Hansen KJ. Survival of young patients after abdominal aortic aneurysm repair. J Vasc Surg. 2002 Jan;35(1):94-9.

Cherr GS, Motew SJ, Travis JA, Fingerle J, Fisher L, Brandl M, Williams JK, Geary RL. Metalloproteinase inhibition and the response to angioplasty and stenting in atherosclerotic primates. Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):161-6.

Travis JA, Fuller SB, Ligush J Jr, Plonk GW Jr, Geary RL, Hansen KJ. Diagnosis and treatment of paradoxical embolus. J Vasc Surg. 2001 Nov;34(5):860-5.

Cherr GS, Travis JA, Ligush J Jr, Plonk G, Hansen KJ, Braden G, Geary RL. Infection is an unusual but serious complication of a femoral artery catheterization site closure device. Ann Vasc Surg. 2001 Sep;15(5):567-70.

Travis JA, Hughes MG, Wong JM, Wagner WD, Geary RL. Hyaluronan enhances contraction of collagen by smooth muscle cells and adventitial fibroblasts: Role of CD44 and implications for constrictive remodeling. Circ Res. 2001 Jan 19;88(1):77-83.

Adams LD, Geary RL, McManus B, Schwartz SM. A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media. Circ Res. 2000 Sep 29;87(7):623-31.

Travis JA, Hansen KJ, Miller PR, Dean RH, Geary RL. Aneurysmal degeneration and late rupture of an aortorenal vein graft: case report, review of the literature, and implications for conduit selection. J Vasc Surg. 2000 Sep;32(3):612-5. Review.

Fukuhara M, Geary RL, Diz DI, Gallagher PE, Wilson JA, Glazier SS, Dean RH, Ferrario CM. Angiotensin-converting enzyme expression in human carotid artery atherosclerosis. Hypertension. 2000 Jan;35(1 Pt 2):353-9.

Book Chapters:

Geary RL, Clowes AW: Intimal hyperplasia as a cause of graft failure after vascular reconstruction, in Spartera C, Courbier R, Fiorani P, Imparato AM (editors): "Redo" Vascular Surgery: Renal, Aorto-Iliac and Infrainguinal Areas, Serono Symposia Volume 87. New York, Raven Press, 1992, pp 29-42.

Geary RL, Schwartz SM: Intimal hyperplasia is the wrong target: restenosis as a failure of remodeling, in Lafont A, Topol E, (editors): Arterial Remodeling: A Critical Factor in Restenosis. Norwell MA, Kluwer Academic Publishers, 1996; pp 199-230.

Geary RL, Clowes AW, Clowes MM: Transplantation of transduced smooth muscle cells: A vehicle for local and systemic gene therapy, Chapter 56, in Zilla P, Greisler HP, (editors): Tissue Engineering of Prosthetic Vascular Grafts. Austin TX, Landes Bioscience, 1998; pp 605-612.

Geary RL: Pathobiology of Vascular Disease, in Norton JA, Bollinger RR, Chang AE, Lowery SF, Mulvihill SJ, Pass HI, Thompson RW, (editors): Surgery: Basic Science and Clinical Evidence. New York, Springer-Verlag, 2001; pp 987-1004.