- A June, 2004, article by Dr. Cui and Dr. Willingham, "The effect of aging on cellular immunity against cancer in SR/CR mice," published in the journal Cancer Immunology, Immunotherapy.
- Dr. Cui wrote an essay, "The winding road to the discovery of the SR/CR mice" for the journal Cancer Immunity, published by the Academy of Cancer Immunology in October, 2003.
- The first major scientific publication based on this research was published in the journal Proceedings of the National Acadamy of Sciences:
Cui Z, Willingham MC, Hicks AM, Alexander-Miller MA, Howard TD, Hawkins GA, Miller MS, Weir HM, Du W, DeLong CJ. Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6682-7.
Abstract:
We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden, and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately after exposure, cancer cells provoke a massive infiltration of host leukocytes, which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer.
Full text of the article can be read online here.
A printable version of the article can be downloaded here.
Selected Coverage of May 8, 2006 Announcement
- Injected Cells Cure Tumors in Mice, Los Angeles Times, May 9, 2006-05-09
- A Strain of Mice Appears Able to Resist Cancer Cells, New York Times, May 9, 2006
- Cancer Resistance Found to be Transferable in Mice, Scientific American.com May 9, 2006
- Researchers Cure Lethal Cancer in Mice, Voice of America, May 8, 2009
- Mice Put Cancer on Ice, Newsday, May 9, 2006
- Cell Therapy Treatment is Curing Cancer in Mice, Winston-Salem Journal, May 9, 2006
Some Related Articles and Press Coverage from April 2003 Announcement:
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