Rebecca Alexander, PhD
Reynolda Campus-Chemistry Department

Research in our laboratory centers on mechanisms of bacterial protein synthesis, using protein engineering, kinetic studies, and in vitro selection schemes.

Isabelle Berquin, PhD
Pathology

My laboratory is studying the overexpression of the epidermal growth factor receptor (EGFR) that occurs in a subset of breast tumors and is an indicator of poor prognosis.

Urlich Bierbach, PhD
Reynolda Campus-Chemistry Department

Research in our laboratory is concerned with the design of small-molecule agents for the cure and management of life-threatening diseases and for probing and modulating gene regulation.

Hannah Caldas, PhD
Neurosurgery

My laboratory is interested in exploring the functions of the members of the Survivin gene family in cancer and the modulation of these functions as potential therapeutic interventions to combat cancer growth.

Zheng Cui, PhD
Pathology

Current research in our laboratory is focused on two projects:  1.  Innate immunity against cancer in mice and humans, and 2. Lipidomics and metabolipidomics.

Waldemar Debinski, MD, PhD
Microbiology/Immunology & Neurosurgery

The main goal of my laboratory is to advance research in the areas of unmet needs in medicine; a majority of primary brain tumors represents such needs. Our focus is on the identification of molecular markers/targets that are specific to brain tumors.

Purnima Dubey, PhD
Pathology

My lab is interested in mechanisms of tumor progression.  We study the role of the protein Prostate Stem Cell Antigen in cancer metastasis.  We also investigate the adaptive immune system in prostate cancer progression, and utilize non-invasive imaging techniques to follow the localization and function of T lymphocytes at the tumor site. 

Kazushi Inoue, PhD
Pathology

The projects in our lab have been focused on the characterization of the novel tumor suppressor gene Dmp1 (Dmtf1). Dmp1 is a Myb-family transcription factor that prevents tumor formation by activating the Arf-p53 tumor suppressor pathway.

Paul Jones, PhD
Reynolda Campus-Chemistry Department

I am interested in studying how photochemistry is used in nature and in developing photochemical methods to generate synthetically and medically significant products.

S. Bruce King, PhD
Reynolda Campus-Chemistry Department

Our research program is based on a combination of organic chemistry and biochemistry directed towards understanding the various roles nitric oxide (NO) performs in biological systems.

Greg Kucera, PhD
Hematology/Oncology

The general aim of my research is to influence the potential for clinical trials through laboratory investigations of novel anticancer drugs or combinations of anticancer drugs that affect cellular proliferation through signaling pathways.

Tim Kute, PhD
Pathology

My interests are in the better characterization of breast cancer tumors for prognostic utility and for determining which treatments should be given.

Linda Metheny-Barlow, PhD
Radiation Oncology

My laboratory studies angiogenesis and cell-cell interactions in the tumor microenvironment.  Our goal is to identify strategies both to inhibit tumor angiogenesis as well as normalize the tumor vasculature to enhance the effectiveness of current therapeutic strategies.

Charles Morrow, MD, PhD
Biochemistry

The major focus of my research concerns the role of combined actions of glutathione transferases (GST) and the multidrug resistance protein (MRP) family efflux transporters in the emergence of anticancer drug resistance and carcinogen detoxification.

David Ornelles, PhD
Microbiology & Immunology

My research concerns the oncogenes of adenovirus that circumvent host cell restrictions to virus replication.  Our research addresses the rational design of replicating, oncolytic viruses for cancer therapy and a possible role for adenovirus in the etiology of childhood leukemia. 

W. Jeff Petty, MD
Hematology/Oncology

My research focuses on two distinct but convergent signaling pathways: the epidermal growth factor receptor (EGFR) pathway and the retinoic acid receptor (RAR) pathway. By understanding mechanisms of response or resistance to drugs that target these pathways, I hope to develop effective chemoprevention strategies that could be used to treat early stages lung carcinogenesis.

Mike Robbins, PhD
Radiation/Oncology

Research in my laboratory is focused on defining the pathogenic mechanisms responsible for the development of radiation-induced brain injury, including cognitive impairment, and the application of interventional therapies aimed at preventing this dose-limiting morbidity.

Shay Soker, PhD
Regenerative Medicine

In  my  research  I  am  investigating  the  role  of  VEGF  and  its  receptors  in  neovascularization,  vascular  diseases  and  in  cancer.

Suzy Torti, PhD
Biochemistry

For many years, it has been known that individuals with increased iron stores exhibit an increased risk of tumor formation, and that proteins of iron metabolism are frequently up-regulated in tumors.  My laboratory is interested in exploring the molecular basis of these observations, their biological implications, and the therapeutic opportunities they may provide.

Alan Townsend, PhD
Biochemistry

Exposure of cells to reactive electrophilic agents can damage cellular protein and lipid structures, and can cause genetic changes leading to abnormal growth control and cancer. We are interested in the enzymatic mechanisms for activation vs. detoxification of carcinogenic mutagens.

Mark Welker, PhD
Reynolda Campus-Chemistry Department

One of my lab’s long term research goals is to produce nontoxic cancer chemopreventive agents.  A comprehensive cancer treatment strategy will ultimately involve the use of small molecules for both the treatment and prevention of cancer.

Jianfeng Xu, MD, PhD
Human Genomics

My group focuses on prostate cancer gene mapping using various approaches such as genetic linkage studies, family-based and population-based association studies, and molecular positional cloning technique.