Name: Joy L. Little Email address: jlittle@wfubmc.edu Education: B.A. cum laude in Biology, minor in Mathematics, Salem College, 2003 Advisor/Lab: Steven J. Kridel, PhD Current Research: My project in the Kridel lab focuses on delineating the mechanism of cell death induced by Fatty Acid Synthase (FAS) inhibitors in prostate tumor cells. A better understanding of how FAS inhibitors work in tumor cells is crucial to developing these drugs as anti-tumor agents and understanding the biology of FAS-over expressing tumors. Publications: Xu J, Turner A, Little J, Bleecker ER, and Meyers DA (2002) Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error? Journal of Human Genetics. 111, 573-574. Floyd HS, Farnsworth CL, Kock ND, Mizesko MC, Little JL, Dance ST, Everitt J, Tichelaar J, Whitsett JA, and Miller MS (2005) Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis 26(12), 2196-220 . Zhao W, Kridel S, Thorburn A, Kooshki M, Little J, Hebbar S and Robbins M (2006) Fatty acid synthase: a novel target for antiglioma therapy. British Journal of Cancer 95, 869-878. Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ (2007) Inhibition of Fatty Acid Synthase Induces Endoplasmic Reticulum Stress in Tumor Cells. Cancer Research 67(3):1262-1269. Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ (2008) Crosstalk Between the Fatty Acid Synthesis and Proteasome Pathways Enhances UPR Signaling and Cell Death. In Preparation. Little JL, Kridel SJ (2008) Book Chapterin Subcellular Biochemistry: Lipids in Health and Disease. In Preparation. Honors and Awards: 2006 Cancer Biology Department Annual Retreat Presentation – Third place Oral Presentations: Salem College, Women in Science Excellence Conference, “Inhibition of Fatty Acid Synthase Induces Endoplasmic Reticulum Stress in Tumor Cells”, 9 March 2007. 2nd Annual Symposium on the Role of Dietary Fatty Acids in the Prevention and Treatment of Disease, Center for Botanical Lipids, Winston-Salem, NC, “Fatty Acid Synthase Inhibitors Induce ER stress-Dependent Cell Death” October 24-26, 2007. Hobbies – Other: Reading, movies, travel, cooking, surgery |