Name: Shihua Wang Email address: shwang@wfubmc.edu Education: M. D. 1994 Zhejiang Medical University, Hangzhou, China M. M. 1997 Zhejiang Medical University, Hangzhou, China Ph. D. 2003 The Ohio State University, Columbus, OH Advisor/Lab: Yong Q. Chen Current Research: Cholesterol is the precursor of the androgen which promotes prostate carcinogenesis. ATP-binding cassette transporter A1 (ABCA1) is the cholesterol transporter mediating cholesterol efflux. My current research is creating an ABCA1 and Pten double knock-out mouse model. The objective of my research is to examine the effects of cholesterol in the development of prostate cancer and to study dietary interventions in the prevention of prostate cancer in deficiency of ABCA1. Publications: Wang S, Xu J and Zhu Y. Relationship between Expression of nm23-H1, c-erBb-2 Proteins and Metastasis in Colorectal Carcinoma. J. Clin. Exp. Pathol. 1998, 14 (5): 472-474. Wang S, DeGroff VL, Clinton SK. Soy and Tomato Polyphenols Inhibit Insulin-like Growth Factor-I Stimulated Prostate Cancer Cell Proliferation and Apoptotic-Resistance via Multiple Intracellular Signaling Pathways Involving Tyrosine Kinase. Journal of Nutrition. 2003, 133 (7): 2367-2376. Liao Z, Wang S, Boileau TW, Erdman JW Jr, Clinton SK. Increased Phospho-AKT is Associated with Loss of the Androgen Receptor during the Progression of N-methyl-N-nitrosourea-induced Prostate Carcinogenesis in Rats. The Prostate, 2005, 64(2):186-99. Liao Z, Wang S, Wiegers B, and Clinton SK. Energy Balance Alters Dunning R3327-H Prostate Tumor Architecture, Androgen Receptor Expression and Nuclear Morphometry in Rats. The Prostate, 2006, 66(9):945-53. Canene-Adams K, Lindshield BL, Wang S, Jeffery EH, Clinton SK, Erdman JW Jr. Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas. Cancer Research, 2007, 67(2):836-43. Guo Y, Wang S, Hoot DR and Clinton SK. Genistein Suppression of VEGF-Mediated Autocrine and Paracrine Interactions between Prostate Cancer Cells and Vascular Endothelial Cells. Journal of Nutritional Biochemistry, 2007, 18(6):408-17. Honors and Awards: 2003-2004 DOD Post-doctoral Traineeship Award Hobbies – Other: Read to learn any time |