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Leslie B. Poole, Ph.D.

Leslie B. Poole, Ph.D.

Professor, Biochemistry
Contact Information
Office:
3367166711
Clinical Specialties
Cancer Cell Biology
Education & Training
DegreeOrganizationIssued
  BAWake Forest University1980
  PhDWake Forest University1988
Memberships
American Society of Biochem & Molecular Biology
Protein Society
American Society of Microbiology
Society for Free Radical Biology and Medicine
American Chemical Society
Leslie B. Poole, Ph.D.

Leslie B. Poole, Ph.D.

Professor, Biochemistry
Contact Information
Office:
3367166711
Research Interests
technology /technique developm, information sciences, urinary system/kidney, basic mechanisms, biological/chemical compounds, molecular biology/molecular me, cell growth, differentiation,d, infectious diseases, biotechnology, computer science, microorganisms, structural biology
Recent Publications
Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds, Biochemistry, 09/24/2009

Typical 2-Cys peroxiredoxins--structures, mechanisms and functions, FEBS J, 06/19/2009

Detection of cysteine sulfenic acid formation: role in reactive oxygen species-dependent VEGF signaling linked to endothelial migration [abstract], Circulation, 05/04/2009

Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase, Methods Mol Biol, 03/19/2009

Cysteine pKa values for the bacterial peroxiredoxin AhpC, Biochemistry, 03/10/2009

Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H2O2, Free Radic Biol Med, 12/03/2008

Sulfenic acid-reactive compounds and their methods of synthesis [patent], Wake Forest University Health Sciences, assignee; US patent 7,294,748; 2007 Nov 13;, 08/27/2008

Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin, Proc Natl Acad Sci U S A, 08/07/2008

Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pKa values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Anal Biochem, 06/03/2008

Discovering mechanisms of signaling-mediated cysteine oxidation, Curr Opin Chem Biol, 04/07/2008

Substrate specificity and chemical characterization of a bacterial peroxiredoxin, AhpC [abstract], Free Radic Biol Med, 04/07/2008

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid, Protein Sci, 04/07/2008

The role of cysteine sulfenic acid formation during NF-kappa B-mediated signaling [abstract], Free Radic Biol Med, 04/04/2008

Cysteine sulfenic acid detection in signal transduction pathways [abstract], Free Radic Biol Med, 04/02/2008

Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity, Mol Cell, 02/25/2008

The requirement of reversible cysteine sulfenic acid formation for T cell activation and function, J Immunol, 02/01/2008

The catalytic mechanism of peroxiredoxins, Subcell Biochem, 02/01/2008

Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins, Bioconjug Chem, 01/17/2008

Cysteine reactivity and thiol-disulfide interchange pathways in AhpF and AhpC of the bacterial alkyl hydroperoxide reductase system, Biochemistry, 08/09/2007

The shuffle index and evaluation of models of signal transduction pathways, Proceedings of the 45th Annual ACM Southeast Regional Conference; 2007 Mar 23-24; Winston-Salem (NC), 06/21/2007

Chondrocyte MMP-13 expression in response to alpha 5 beta 1 integrin stimulation requires protein sulfenic acids as signaling intermediates [abstract], Arthritis Rheum, 03/29/2007

Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery, J Cell Biol, 03/28/2007
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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