Selected publications

Trojer, P., Li, G., Sims, R. J., Vaquero, A., Kalakonda, N., Boccuni, P., Lee, D., Erdjument-Bromage, H., Tempst, P., Nimer, S., Wang, Y.-H., and Reinberg, D. (2007) L3MBTL1, a histone methylation dependent chromatin lock. Cell, 129: 915-928.

Wang, Y.-H. (2007) Chromatin Structure of Repeating CTG/CAG and CGG/CCG Sequences in Human Diseases. In “DNA Structures, Genome Instability and Human Disease”, Ed. S. M. Mirkin, Frontiers in Biosciences 12:4731-4741.

Wang, Y.-H. (2007) Role of DNA Packaging on Rare Fragile Site Expression. In “Common and Rare Fragile Sites”, Ed. I. Arrieta, & G. R.  Sutherland, Nova Science Publishers Inc. NY.

Rubtsov, M. A., Polikanov, Y. S., Bondarenko, V. A., Wang, Y.-H., and Studitsky, V. M. (2006) Chromatin Structure Can Strongly Facilitate Enhancer Action Over a Distance. Proc. Natl. Acad. Sci. U.S.A.  103:17690-17695.

Kar, K., Amin, P., Bryan, M. A., Persikov, A., Mohs, A., Wang, Y.-H., Brodsky, B. (2006) Mechanism of Self-Association of a Collagen Triple-Helix Model Peptide.  J. Biol. Chem.  281:33283-33290.

Khan, Q. A., Barbieri, C. B., Srinivasan, A. R., Wang, Y.-H., LaVoie, E. J., and Pilch, D. S. (2006) Drug Self-Association Modulates the Cellular Bioavilability of DNA Minor Groove-Directed Terbenzimidazoles.  J.  Med. Chem. 49:5245-5251.

Wang, Y.-H. (2006) Chromatin Structure of Human Chromosomal Fragile Sites. Cancer Letters  232:70-78.

Mulvihill, D. J., Nichol, K., Hagerman, K. A., Pearson, C. E., and Wang, Y.-H. (2005) Effect of CAT or AGG Interruptions and CpG Methylation on Nucleosome Assembly on Triplet Repeats of SCA1 and FRAXA. J. Biol. Chem. 280:4498-4503.

Levine, M. K., Wang, Y.-H., and Patel, S.S. (2004) The Functional Interaction of Hepatitis C Virus Helicase Molecules is Responsible for Unwinding Processivity. J. Biol. Chem. 279:26005-26012.

Lowrimore, P., D. J. Mulvihill, Epstein, A., McCormack, M., Wang, Y.-H. (2004) CAG Nucleotide Repeat Profiles in Persons with Schizophrenia or Schizoaffective Disorders With and Without Tardive Dyskinesia: Pilot Study. Am. J. of Med. Genet. 128:15-18.

Mulvihill, D. J., and Wang, Y.-H. (2004) Two Breakpoint Clusters at Fragile Site FRA3B Form Phased Nucleosomes. Genome Research. 14:1350-1357.

Loyola, A., Huang, J.-Y., LeRoy, G., Hu, S., Wang, Y.-H., Donnelly, R. J., Lane, W., Lee, S.-C., and Reinberg, D. (2003) Functional Analysis of The Subunits of The Chromatin Assembly Factor RSF. Mol. Cell. Biol. 23:6759-6768.

Pearson, C. E., Tam, M., Wang, Y.-H., Montgomery, S. E., Dar, A. C., Cleary, J. D., and Nichol, K. (2002) Slipped-strand DNAs Formed by Long (CAG)·(CTG) Repeats: Slipped-out Repeats and Slip-out Junctions. Nucl. Acids. Res. (cover) 30: 4534-4547.

Cleary, J., Nichol, K., Wang, Y.-H. and Pearson, C. E. (2002) Replication Fork Dynamics and Dynamic Mutations of (CTG)•(CAG) Repeats: Evidence of Cis-Acting Factors. Nature Genetics  31:37-46.

Hsu, Y., and Wang, Y.-H. (2002) Human Fragile Site FRA16B DNA Excludes Nucleosomes in the Presence of Distamycin. J. Biol. Chem. 277:17315-17319.

Loyola, A., LeRoy, G., Wang, Y.-H. and Reinberg, D. (2001) Reconstitution of Recombinant Chromatin Establishes a Requirement for Histone-Tail Modifications During Chromatin Assembly and Transcription. Gene & Dev. 15: 2837-2851.

Wang, Y.-H. (2000) DNA structures of Biological Relevance, Studies of unusual sequences. In “Encyclopedia of Analytical Chemistry: Instrumentation and Applications”, Ed. R. A. Meyers.

Kirkpatrick, D, T., Wang, Y.-H., Dominska, M. Griffith, J. and Petes, T. (1999) Control of Meiotic Recombination and Gene Expression in Yeast by a Simple Repetitive DNA Sequence that Excludes Nucleosomes. Mol. Cell. Biol. 19:7661-7671.

Griffith, J. D. and Wang, Y.-H. (1998) Nucleosome Analysis and Diseases of Chromatin Structure. In “Genetic Instabilities and Hereditary Neurological Diseases” Eds., R. D. Wells and S. T. Warren.

Pearson, C. E., Wang, Y.-H., Griffith, J., and Sinden, R. R. (1998) Structural Analysis of Slipped-stranded DNA (S-DNA) Formed in (CTG)n/(CAG)n Repeats from Myotonic Dystrophy Locus. Nucleic Acids Research (cover) 26:816-823.

Griffith, J. D., Lee, S. and Wang, Y.-H. (1997) Visualizing nucleic acids and their complexes using electron microscopy. Curr. Opin. Struct. Biol. 7:362-366.

Wang, Y.-H., Gellibolian, R., Shimizu, M., Wells, R. D. and Griffith, J. D. (1996) Long CCG triplet blocks exclude nucleosomes: a possible mechanism for the nature of fragile sites in chromosomes. J. Mol. Biol. 263:511-516.

Wang, Y.-H. and Griffith, J. D. (1996) Methylation of expanded CCG triplet repeat DNA from fragile X syndrome patients enhances nucleosome exclusion. J. Biol. Chem. 271:22937-22940.

Wang, Y.-H. and Griffith, J. D. (1996) The [(G/C)₃NN]n motif: a common DNA repeat that excludes nucleosomes. Proc. Natl. Acad. Sci. U.S.A.  93:8863-8867.

Nakamura, T., Wang, Y.-H., Zaug, A. J., Griffith, J. D., and Cech, T. R. (1995) Visualization of the Relative Orientation of Helical Elements in Tetrahymena Group I Ribozyme by Electron Microscopy. EMBO J. (cover) 14:4849-4859.

Wang, Y.-H., and Griffith, J. D. (1995) Expanded CTG Triplet Blocks from the Myotonic Dystrophy Gene Create the Strongest Known Natural Nucleosome Positioning Elements. Genomics  (cover) 25:570-3.

Murphy, F., Wang, Y.-H., Griffith, J. D. and Cech, T. R. (1994) Coaxially Stacked RNA Helices in the Catalytic Center of the Tetrahymena Ribozyme. Science  265:1709-1712.

Wang, Y.-H., Amirhaeri, S., Kang, S., Wells, R. D., and Griffith, J. D. (1994) Preferential Nucleosome Assembly at DNA Triplet Repeats from the Myotonic Dystrophy Gene. Science  265:669-671.

Wang, Y.-H., Murphy, F., Cech, T. R., and Griffith, J. D. (1994) Visualization of A Tertiary Structure Domain of the Tetrahymena Group I Intron by Electron Microscopy. J. Mol. Biol. 236:64-71.

Wang, Y.-H., Bortner, C. D., and Griffith, J. D. (1993) RecA Binding to Bulge and Mismatch Containing DNA: Certain single base mismatches provide strong signals for RecA binding, equal to multiple base bulges. J. Biol. Chem. 268:17571-17577.

Wang, Y.-H., Barker, P. E., and Griffith, J. D. (1992) Visualization of Diagnostic Heteroduplex DNAs from Cystic Fibrosis DeletionHeterozygotes Provides an Estimate of the Kinking of DNA by Bulged Bases. J. Biol. Chem. 267:4911-4915.

Wang, Y.-H., Howard, M. T., and Griffith, J. D. (1991) Phased Adenine Tracts in Double-Stranded RNA do Not Induce Sequence-DirectedBending. Biochemistry 30:5443-5449.

Wang, Y.-H. and Griffith, J. D. (1991) Effects of Base Composition and Flanking Sequences on the Kinking of DNA by Bulged Bases.Biochemistry 30:1358-1363.