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Lawrence L. Rudel, Ph.D.

Lawrence L. Rudel, Ph.D.

Section Head, Pathology
Professor, Pathology-Comparative Medicine
WFU Primate Center
Contact Information
Office:
336-716-2823
Fax:
336-716-6279
Education & Training
  BSColorado State University1963
  MSUniv Of Arkansas For Medical Sci1965
  PhDUniv Of Arkansas For Medical Sci1969
Memberships
American Association of Pathologists
American Association of Advancement of Science
Aha - Council On Arteriosclerosis
Lawrence L. Rudel, Ph.D.

Lawrence L. Rudel, Ph.D.

Section Head, Pathology
Professor, Pathology-Comparative Medicine
WFU Primate Center
Contact Information
Office:
336-716-2823
Fax:
336-716-6279
Research Interests
atherosclerosis/thrombosis, cardiovascular system, biological/chemical compounds
Recent Publications
Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA: cholesterol acyltransferase 2 (ACAT2) in monkeys, Arterioscler Thromb Vasc Biol, 10/21/2009

Cholesterol esterification by Acyl-CoA cholesterol:acyl transferase 2 increases intestinal sterol absorption efficiency [abstract], Arterioscler Thromb Vasc Biol, 10/08/2009

Dietary n-3 fatty acids have minimal effects on intestinal Niemann-Pick C1 like 1 expression and cholesterol absorption [abstract], Arterioscler Thromb Vasc Biol, 10/07/2009

Alpha linolenic acid-derived n-3 long-chain PUFAs are not as effective in atheroprotection as dietary PUFAs from fish oil despite similar plasma and hepatic enrichments in n-3 PUFAs [abstract], Arterioscler Thromb Vasc Biol, 10/06/2009

Targeted deletion of hepatocyte ABCA1 induces futile cycling of VLDL production and clearance in C57BL/6 mice [abstract], Arterioscler Thromb Vasc Biol, 10/06/2009

Carotid atherosclerosis progression and ACAT inhibition [letter], JAMA, 09/28/2009

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome, Curr Opin Lipidol, 09/22/2009

Control of ACAT2 liver expression by HNF4alpha: lesson from MODY1 patients, Arterioscler Thromb Vasc Biol, 09/11/2009

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent, J Lipid Res, 06/23/2009

The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of Acyl-CoA: cholesterol acyltransferase, Chem Pharm Bull (Tokyo), 06/22/2009

Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism;, Circulation, 05/28/2009

Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo, J Lipid Res, 05/28/2009

LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat, J Lipid Res, 05/28/2009

A novel role for Abca1-generated large nascent HDL in the regulation of VLDL triglyceride secretion [abstract], Circulation, 04/20/2009

Concerns regarding lipoprotein particle measurement by ion mobility analysis [letter], Clin Chem, 03/10/2009

Selective inhibition of acyl-CoA : cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species, J Antibiot, 01/30/2009

Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA : cholesterol acyltransferase 2 isozyme, J Antibiot, 12/29/2008

Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages, Biol Pharm Bull, 12/01/2008

Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis, Circulation, 11/18/2008

Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition, J Biol Chem, 11/06/2008

Identification of putative active site residues of ACAT enzymes, J Lipid Res, 11/05/2008

In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids, J Biol Chem, 08/14/2008

Mice lacking ABCA1 and ACAT2 have surface-rich, core-depleted LDL due to LCAT deficiency [abstract], Arterioscler Thromb Vasc Biol, 07/29/2008

Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2, Arterioscler Thromb Vasc Biol, 07/28/2008

Microsomal triglyceride transfer protein enhances cellular cholesterol esterification by relieving product inhibition [abstract], Arterioscler Thromb Vasc Biol, 07/23/2008

Dietary flaxseed oil compared to monounsaturated fat limits hepatic cholesteryl ester deposition in a mouse model of atherosclerosis [abstract], Arterioscler Thromb Vasc Biol, 07/22/2008

Inhibition of stearoyl-CoA desaturase 1 (SCD1) dissociates insulin resistance and obesity from atherosclerosis [abstract], Arterioscler Thromb Vasc Biol, 07/21/2008

ATP-binding cassette transporter G5/G8 prevents accumulation of toxic levels of phytosterols in dietary phytosterol-challenged mice [abstract], Arterioscler Thromb Vasc Biol, 07/21/2008

Hepatic-specific deletion of ABCA1 promotes PI3 kinase-dependent VLDL maturation: a novel role for ABCA1 in the regulation of VLDL triglyceride assembly [abstract], Arterioscler Thromb Vasc Biol, 07/21/2008

Identification of the interaction site within acyl-CoA: cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A, J Biol Chem, 06/11/2008

Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss, J Biol Chem, 06/10/2008

Monounsaturated fatty acids and atherosclerosis: opposing views from epidemiology and experimental animal models, Curr Atheroscler Rep, 05/29/2008

Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients, J Lipid Res, 04/02/2008

Mechanisms by which botanical lipids affect inflammatory disorders, Am J Clin Nutr, 03/28/2008

Diet effects on atherosclerosis in mice, Curr Drug Targets, 01/17/2008

Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr-/- mice, J Clin Invest, 12/10/2007

CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells, J Lipid Res, 11/20/2007

NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells, Biochem J, 11/20/2007

ACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins, J Lipid Res, 11/05/2007

Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys, Obesity, 10/16/2007

Characterization and heritability of obesity and associated risk factors in vervet monkeys, Obesity, 10/16/2007

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe, J Clin Invest, 10/15/2007

HNF4 alpha is essential for ACAT2 regulation in human: lesson from the MODY patients [abstract], Atheroscler Suppl, 10/10/2007

Selective delipidation of HDL in plasma produces pre-beta HDL effective in reverse cholesterol transport in vivo in monkeys [abstract], Atheroscler Suppl, 10/10/2007

Reduction of ACAT2 is an important effect of cholesterol synthesis inhibition in human livers [abstract], Atheroscler Suppl, 10/09/2007

ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences [abstract], Atheroscler Suppl, 10/08/2007

Reduced hepatic ACAT2 activity is part of the integrated response to inhibition of cholesterol synthesis in humans [abstract], Arterioscler Thromb Vasc Biol, 08/13/2007

ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences [abstract], Arterioscler Thromb Vasc Biol, 08/09/2007

Acyl-Coa:cholesterol acyltransferase 2 and ATP-binding cassette half transporters G5 and G8 differentially alter hepatic lipoprotein secretion and composition [abstract], Arterioscler Thromb Vasc Biol, 08/07/2007

Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice, J Lipid Res, 07/18/2007

Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice, Arterioscler Thromb Vasc Biol, 06/26/2007

Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee, Circulation, 06/13/2007

Probing the role of hepatic cholesterol esterification in atherosclerosis promotion via liver-specific depletion of ACAT2 [abstract], FASEB J, 06/13/2007

PyripyropeneA (PPPA) specifically inhibits acyl coenzyme A (CoA):cholesterol acyltransferase-2(ACAT2) by interacting with the enzyme near its C-terminal end [abstract], FASEB J, 06/13/2007

Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes, J Antibiot, 06/06/2007

Summary of American Heart Association Diet and Lifestyle Recommendations Revision 2006 [editorial], Arterioscler Thromb Vasc Biol, 04/26/2007

Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers, J Org Chem, 12/12/2006

Liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/-mice, Arterioscler Thromb Vasc Biol, 10/13/2006
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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