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Fred W. Perrino, Ph.D.

Fred W. Perrino, Ph.D.

Professor, Biochemistry
Comprehensive Cancer Center
Contact Information
Office:
336-716-4349
Education & Training
  BSOhio State University1979
  PhDUniversity of Cincinnati1986
Memberships
American Association of Cancer Research
New York Academy of Sciences
American Society of Biochem & Molecular Biology
American Society of Microbiology
Fred W. Perrino, Ph.D.

Fred W. Perrino, Ph.D.

Professor, Biochemistry
Comprehensive Cancer Center
Contact Information
Office:
336-716-4349
Research Interests
biological/chemical compounds, basic mechanisms, immunology/allergy/inflammatio, rare diseases, biomaterials, molecular biology/molecular me
Recent Publications
DNA binding induces active site conformational change in the human TREX2 3'-exonuclease, Nucleic Acids Res, 05/08/2009

A DNA polymerase-alpha.primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells, J Biol Chem, 04/20/2009

RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases, J Mol Med, 02/11/2009

Lesion bypass of N2-ethylguanine by human DNA polymerase Iota, J Biol Chem, 01/30/2009

The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease, J Biol Chem, 12/19/2008

Cooperative DNA binding and communication across the dimer interface in the TREX2 3 '--> 5 '-exonuclease, J Biol Chem, 11/11/2008

Mutations in the 3 '-5 ' DNA exonuclease TREX1 cause monogenic and complex forms of lupus erythematosus [abstract], Eur J Pediatr, 04/02/2008

Mutations in the gene encoding the 3 '-5 ' DNA exonuclease TREX1 are associated with systemic lupus erythematosus, Nat Genet, 12/03/2007

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus, J Mol Med, 07/25/2007

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome, Am J Hum Genet, 07/13/2007

WRN exonuclease activity is blocked by DNA termini harboring 3 degree obstructive groups, Mech Ageing Dev, 06/28/2007

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering, J Biol Chem, 04/23/2007

Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex, J Biol Chem, 02/01/2007

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death, Mol Cell, 10/30/2006

Replication of N(2)-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293, Chem Res Toxicol, 10/23/2006

Mutagenesis by exocyclic alkylamino purine adducts in Escherichia coli, Mutat Res, 10/12/2006
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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