School of Medicine

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Thomas Hollis, Ph.D.

Associate Professor, Biochemistry

Comprehensive Cancer Center

Contact Information

Office:

336-716-0768

Education & Training

	BS	Florida State University	1992
	PhD	University of Texas-Austin	1997

Memberships

American Society of Biochem & Molecular Biology

American Crystallographic Association

Thomas Hollis, Ph.D.

Associate Professor, Biochemistry

Comprehensive Cancer Center

Contact Information

Office:

336-716-0768

Research Interests

cancer/oncogenesis, microorganisms, lymphatic & reticulo-endotheli, animals, cells/membranes/tissu, biological/chemical compounds, molecular biology/molecular me, immunology/allergy/inflammatio, cell growth, differentiation,d, basic mechanisms, structural biology

Recent Publications

DNA binding induces active site conformational change in the human TREX2 3'-exonuclease, Nucleic Acids Res, 05/08/2009

The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response, Nucleic Acids Res, 02/19/2009

RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases, J Mol Med, 02/11/2009

Small molecule induction of MSH2-dependent cell death suggests a vital role of mismatch repair proteins in cell death, DNA Repair, 02/02/2009

Lesion bypass of N2-ethylguanine by human DNA polymerase Iota, J Biol Chem, 01/30/2009

The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease, J Biol Chem, 12/19/2008

Cooperative DNA binding and communication across the dimer interface in the TREX2 3 '--> 5 '-exonuclease, J Biol Chem, 11/11/2008

Mutations in the 3 '-5 ' DNA exonuclease TREX1 cause monogenic and complex forms of lupus erythematosus [abstract], Eur J Pediatr, 04/02/2008

DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG), EMBO J, 10/09/2007

Structural basis for 3-methyladenine recognition and removal by a highly-specific DNA glycosylase: the crystal structure of TAG in complex with DNA [abstract], J Biomol Struct Dyn, 10/08/2007

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus, J Mol Med, 07/25/2007

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome, Am J Hum Genet, 07/13/2007

Crystallization of protein-DNA complexes, Methods Mol Biol, 04/25/2007

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering, J Biol Chem, 04/23/2007

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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