Maryam Ahmed
Molecular mechanisms governing cellular susceptibility or resistance to virus infections, viral pathogenesis, development of viral vectors for anti-tumor therapies.

Peter Antinozzi
Functional mapping and analysis of disease-susceptibility loci; metabolism-secretion coupling in pancreatic beta-cells; development of high-throughput, high-content cell-based assays.

Donald W. Bowden
Molecular genetic analysis of human diseases: diabetes, diabetes complications, hypertension, vision disorders.

Al Claiborne
Structural and mechanistic studies of unique flavoproteins involved in streptococcal oxygen metabolism; catalytic functions of the flavin coenzymes.

Larry W. Daniel
Signal transduction pathways and their alterations in cancer and inflammation, mechanism of action of phorbol diester tumor promoters; regulation of protein kinase C, phospholipase D, Raf-1 and cyclooxygenase-2.

Roy R. Hantgan
Integrin structure and function; molecular and cellular mechanisms of blood coagulation and fibrinolysis.

Thomas Hollis
Structure and function of DNA repair proteins and Fanconi anemia associated proteins; protein crystallography.

David A. Horita
Structural biology of DNA repair and chromatin-mediated transcription regulation.

Susan M. Hutson
Structure-function of vitamin B6-dependent enzymes; nutrient gene regulation; excitatory amino acids and seizure control.

Mark O. Lively
Cellular roles and mechanisms of catalysis of novel proteolytic enzymes; structural analysis of proteins and polypeptides.

W. Todd Lowther
Repair of the oxidative damage to free methionine and methionine within proteins; macromolecular X-ray crystallography; enzyme mechanisms.

Douglas S. Lyles
Virus assembly; antiviral cytotoxic T-cells; membrane protein structure.

Linda C. McPhail
Biochemistry of phagocyte function, specifically oxidative metabolism; mechanisms of intracellular signal transduction.

Charles S. Morrow
Synergy between drug efflux pumps and conjugating enzymes in cancer drug and carcinogen resistance; Regulation of genes associated with xenobiotic detoxification.

Derek Parsonage
Structure-function studies of the FAD-dependent streptococcal NADH peroxidase and NADH oxidase; site-directed mutagenesis.

Fred W. Perrino
Molecular mechanisms of mutagenesis during DNA replication in animal cells; use of in vitro model systems.

Leslie B. Poole
Antioxidant enzyme systems; flavoprotein structure-function relationships; redox-active cystine disulfide centers.

Lawrence Rudel
Plasma lipoprotein metabolism and regulation of apolipoprotein gene expression; cholesterol transport and trafficking.

Susan Sergeant
Cellular signaling pathways in the human neutrophil.

Peter B. Smith
In vitro expression of mammalian monooxygenase enzymes.

Michael J. Thomas
Biological oxidations involving oxygen and oxy-radicals; biological mass and NMR spectroscopy; organic synthesis and reaction mechanisms.

Suzy V. Torti
Proteins of iron metabolism: role in inflammation and cancer; transcriptional regulation; structure and function.

Alan J. Townsend
Molecular pharmacology of anticancer drugs; mechanisms of resistance to cytotoxic and mutagenic agents; glutathione metabolizing enzymes; aldehyde dehydrogenases.

Yuh-Hwa Wang
Human fragile sites in cancer; Trinucleotide repeat expansion diseases; Chromatin structure; Unusual DNA sequence and structure.

John Wilkinson
Cell death regulation in human disease; caspase activation mechanisms; reactive oxygen species