Investigators in structural biology study the molecular structures and physical properties of proteins, nucleic acids and their complexes. The tools of molecular biology are used to synthesize proteins in large quantities suitable for physical analysis by X-ray crystallography, mass spectrometry, enzymology, and a variety of biophysical methods such as light scattering and sedimentation.

Rebecca Alexander Understanding protein-nucleic acid interactions at the molecular level.

Al Claiborne Structural and mechanistic studies of flavoproteins in streptococcal oxygen metabolism; catalytic functions of flavin coenzymes.

Jacquelyn Fetrow Computational analysis of functional sites in proteins; development of methods to model biological networks from experimental time course data; and analysis of molecular dynamics and motion in proteins.

Roy Hantgan Molecular mechanisms of blood coagulation and fibrinolysis; conformation of proteins in solution.

Tom Hollis X-ray crystallographic studies of DNA repair proteins and Fanconi anemia-associated proteins.

David Horita Nuclear magnetic resonance spectroscopy/structural biology of protein-lipid interactions. 

Daniel Kim-Shapiro Nitrogen oxide signaling in hemoglobin and other heme proteins in normal physiology, disease and therapeutics using various spectroscopies including EPR, light scattering, and time-resolved absorption.

Mark Lively Analysis of protein structure and function using mass spectrometry, proteomics, and bioinformatics; proteolytic enzymes; cell biology and biochemistry of laryngopharyngeal reflux and gastroesophageal reflux disease.

Todd Lowther X-ray crystallographic and biochemical analyses of enzymes that repair the oxidative damage to free and protein-incorporated methionine.

Derek Parsonage Enzymology of bacterial enzymes involved in defending against oxidative stress: enzymes that utilize flavin and cysteine residues at the catalytic site.

Leslie Poole Mechanistic enzymology of bacterial enzymes involved in protection against oxidative stress; novel roles of catalytic cysteine residues.