Studies in this area explore the contribution of specific genes to both physiologic and pathophysiologic processes.  A major focus is on the experimental manipulation of genes and gene expression in animal models and cell-based systems and analyses of phenotypic consequences. 

Peter Antinozzi  Functional mapping of disease-susceptibility loci with emphasis on diabetes; cell-based functional assessment of disease-associated allelic variants; metabolism-secretion coupling in pancreatic beta-cells.

Paul Dawson Regulation and genetics of hepatic and intestinal cholesterol and bile acid metabolism.

Ashok Hegde Molecular biological, electrophysiological, and behavioral approaches to study questions on long-term memory.

Scott Hemby Molecular neuropathophysiology of schizophrenia and substance abuse. 

Ross Holmes Molecular and biochemical approaches to investigate intermediary metabolism in cells related to the synthesis of glycolate and oxalate.

Doug Lyles Virus assembly; molecular pathogenesis of virus infection.

Charles McCall Neutrophil biology and biochemistry; inflammation of lung; signal transduction; phospholipid metabolism; expression of IL-1, TNFa and cyclooxygenase genes in phagocytes.

Lance Miller  Transcriptional and genomic alterations of the "oncogenome" that drive tumorigenesis and predict patient outcomes.

Carol Milligan Neuronal development, degeneration, and plasticity after injury: identification and characterization of differentially expressed genes in motoneuron cell death.

Nila Mishra New therapeutic targets for the treatment and prevention of SLE.

Barbara Nicklas  Research focuses on understanding the metabolic and hormonal adaptations to exercise and dietary interventions in older individuals, and the role of genetics in determining these adaptations. 

Ron Oppenheim Developmental neurobiology; programmed cell death; growth factors and neurotrophic molecules.

David Ornelles Molecular virology of adenovirus; the oncolytic and oncogenic potential of human adenovirus.

John Parks Structure-function relationships of lecithin:cholesterol acyltransferase and high-density lipoproteins.

Tom Register Modulation of the expression of cytokines and connective tissue genes during early atherogenesis.

Greg Shelness Intracellular protein targeting and transport; lipoprotein assembly and secretion.

Mary Sorci-Thomas Regulation of apolipoprotein gene expression; structure-function relationships of apoprotein A-I.

Ann Tallant  Signal transduction; regulation of growth; hypertension; cancer treatment/prevention.

Richard Weinberg Structure and function of human apolipoprotein A-IV (apo A-IV), an intestinal protein synthesized during lipid absorption and incorporated into the surface of nascent chylomicrons.

Bingzhong Xue  Molecular and cellular mechanisms of obesity and insulin resistance. 

Liqing Yu Molecular and cellular basis of cholesterol trafficking in vivo and in vitro.