Rebecca Alexander, PhD  Reynolda Campus-Chemistry Department  Research in our laboratory centers on mechanisms of bacterial protein synthesis, using protein engineering, kinetic studies, and in vitro selection schemes.  Faculty Page  Laboratory Page

Urlich Bierbach, PhD  Reynolda Campus-Chemistry Department  Research in our laboratory is concerned with the design of small-molecule agents for the cure and management of life-threatening diseases and for probing and modulating gene regulation.  Faculty Page  Laboratory Page

Hannah Caldas, PhD  Neurosurgery  My laboratory is interested in exploring the functions of the members of the Survivin gene family in cancer and the modulation of these functions as potential therapeutic interventions to combat cancer growth.  Faculty Page  Laboratory Page

Zheng Cui, PhD  Pathology  Current research in our laboratory is focused on two projects:  1.  Innate immunity against cancer in mice and humans, and 2. Lipidomics and metabolipidomics.  Faculty Page  Laboratory Page

Waldemar Debinski, MD, PhD  Microbiology/Immunology & Neurosurgery  The main goal of my laboratory is to advance research in the areas of unmet needs in medicine; a majority of primary brain tumors represents such needs. Our focus is on the identification of molecular markers/targets that are specific to brain tumors.  Faculty Page  Laboratory Page

Purnima Dubey, PhD  Pathology  My lab is interested in mechanisms of tumor progression.  We study the role of the protein Prostate Stem Cell Antigen in cancer metastasis.  We also investigate the adaptive immune system in prostate cancer progression, and utilize non-invasive imaging techniques to follow the localization and function of T lymphocytes at the tumor site.  Faculty Page  Laboratory Page

Kazushi Inoue, PhD  Pathology  The projects in our lab have been focused on the characterization of the novel tumor suppressor gene Dmp1 (Dmtf1). Dmp1 is a Myb-family transcription factor that prevents tumor formation by activating the Arf-p53 tumor suppressor pathway.  Faculty Page  Laboratory Page

Paul Jones, PhD  Reynolda Campus-Chemistry Department  I am interested in studying how photochemistry is used in nature and in developing photochemical methods to generate synthetically and medically significant products.  Laboratory Page

S. Bruce King, PhD  Reynolda Campus-Chemistry Department  Our research program is based on a combination of organic chemistry and biochemistry directed towards understanding the various roles nitric oxide (NO) performs in biological systems.  Laboratory Page

Greg Kucera, PhD  Hematology/Oncology  The general aim of my research is to influence the potential for clinical trials through laboratory investigations of novel anticancer drugs or combinations of anticancer drugs that affect cellular proliferation through signaling pathways.  Faculty Page  Laboratory Page

Tim Kute, PhD  Pathology  My interests are in the better characterization of breast cancer tumors for prognostic utility and for determining which treatments should be given.  Faculty Page  Laboratory Page

Linda Metheny-Barlow, PhD  Radiation Oncology  My laboratory studies angiogenesis and cell-cell interactions in the tumor microenvironment.  Our goal is to identify strategies both to inhibit tumor angiogenesis as well as normalize the tumor vasculature to enhance the effectiveness of current therapeutic strategies.  Faculty Page  Laboratory Page

Charles Morrow, MD, PhD  Biochemistry  The major focus of my research concerns the role of combined actions of glutathione transferases (GST) and the multidrug resistance protein (MRP) family efflux transporters in the emergence of anticancer drug resistance and carcinogen detoxification.  Faculty Page  Laboratory Page

David Ornelles, PhD  Microbiology & Immunology  My research concerns the oncogenes of adenovirus that circumvent host cell restrictions to virus replication.  Our research addresses the rational design of replicating, oncolytic viruses for cancer therapy and a possible role for adenovirus in the etiology of childhood leukemia.  Faculty Page  Laboratory Page

W. Jeff Petty, MD  Hematology/Oncology  My research focuses on two distinct but convergent signaling pathways: the epidermal growth factor receptor (EGFR) pathway and the retinoic acid receptor (RAR) pathway. By understanding mechanisms of response or resistance to drugs that target these pathways, I hope to develop effective chemoprevention strategies that could be used to treat early stages lung carcinogenesis.  Faculty Page  Laboratory Page

Mike Robbins, PhD  Radiation/Oncology  Research in my laboratory is focused on defining the pathogenic mechanisms responsible for the development of radiation-induced brain injury, including cognitive impairment, and the application of interventional therapies aimed at preventing this dose-limiting morbidity.  Faculty Page  Laboratory Page

Shay Soker, PhD  Regenerative Medicine  In  my  research  I  am  investigating  the  role  of  VEGF  and  its  receptors  in  neovascularization,  vascular  diseases  and  in  cancer.  Faculty Page  Laboratory Page

Suzy Torti, PhD  Biochemistry  For many years, it has been known that individuals with increased iron stores exhibit an increased risk of tumor formation, and that proteins of iron metabolism are frequently up-regulated in tumors.  My laboratory is interested in exploring the molecular basis of these observations, their biological implications, and the therapeutic opportunities they may provide.  Faculty Page  Laboratory Page

Alan Townsend, PhD  Biochemistry  Exposure of cells to reactive electrophilic agents can damage cellular protein and lipid structures, and can cause genetic changes leading to abnormal growth control and cancer. We are interested in the enzymatic mechanisms for activation vs. detoxification of carcinogenic mutagens.  Faculty Page  Laboratory Page

Mark Welker, PhD  Reynolda Campus-Chemistry Department  One of my lab’s long term research goals is to produce nontoxic cancer chemopreventive agents.  A comprehensive cancer treatment strategy will ultimately involve the use of small molecules for both the treatment and prevention of cancer.  Laboratory Page

Jianfeng Xu, MD, PhD  Human Genomics  My group focuses on prostate cancer gene mapping using various approaches such as genetic linkage studies, family-based and population-based association studies, and molecular positional cloning technique.  Faculty Page  Laboratory Page