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Department of Physiology and Pharmacology

 

J. Charles Eldridge, Ph.D.
Professor, Dept. of Physiology and Pharmacology
eldridge@wfubmc.edu
Telephone: (336) 716 8570
Fax: (336) 716 8501


Education: 
B.A. (1965)  -  North Central College, Naperville, IL (Biology/Chemistry)
M.S. (1967)  -  Northern Illinois University, DeKalb, IL (Physiology)
Ph.D. (1971)  - Medical College of Georgia, Augusta, GA (Endocrinology)

Research Area:
Reproductive endocrinology, endocrine toxicology, steroid hormone biochemistry and receptor interaction

Academic Activities:
Consultant in reproductive and endocrine toxicology to the US EPA, the Science Advisory Panel, governmental and industrial research, service to peer-reviewed journals, and membership on the WFU general radiation safety committee.

Activities in Medical & Graduate Education:
Medical: endocrine physiology-pharmacology, small group case-centered learning, Core Teaching Faculty

Medical Education Links

Graduate: endocrine physiology-pharmacology, graduate student courses on scientific professionalism & integrity, bioethics & social responsibility.

Graduate Education Links


Brief Summary of Research:
Our laboratory currently focuses on endocrine toxicology and particularly “endocrine disruptors”, chemicals that may imitate, inhibit or otherwise modulate hormones and the endocrine system. For many years we have investigated the actions of agricultural herbicides, particularly the mechanisms by which these chemicals disrupt estrous cycling in rodent models used for toxicology screens.

We are also using our experience with steroid receptors to uncover details of competitive binding properties of environmentally sensitive chemicals with the estrogen receptor, particularly varying strategies that chemicals use to associate with receptor binding.


Research Links