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Research Interests: S100 proteins in Osteoarthritis
Current Research:
S100 proteins constitute one of the largest groups in the EF-hand calcium-binding protein family and are implicated in various cellular functions. Members of this family are known to exhibit cell and tissue specific expression and up regulated in various human pathologies. My research is focused on understanding the function and regulation of S100A4 in chondrocytes and its role in development of osteoarthritis (OA). Recent work has focused on the cell signaling pathways activated by S100A4 which regulate the expression of matrix-metalloproteinase (MMP).
Recent Publications
Bose S, Kalra S, Yammani RR, Ahuja R, Seetharam B. Plasma membrane delivery, endocytosis and turnover of transcobalamin receptor in polarized human intestinal epithelial cells. J Physiol. 2007 Jun 1;581(Pt 2):457-66. Epub 2007 Mar 8.
Yammani RR, Carlson CS, Bresnick AR, Loeser RF. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum. 2006 Sep;54(9):2901-11.
Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SD. Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum. 2005 Aug;52(8):2376-85.
Kalra S, Li N, Yammani RR, Seetharam S, Seetharam B. Cobalamin (vitamin B12) binding, phylogeny, and synteny of human transcobalamin. Arch Biochem Biophys. 2004 Nov 15;431(2):189-96.
Kalra S, Seetharam S, Yammani RR, Seetharam B. Rat transcobalamin: cloning and regulation of mRNA expression. J Physiol. 2004 Apr 15;556(Pt 2):623-35. Epub 2004 Jan 14.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine
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