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Charles E. McCall, MD
Professor, Internal Medicine - Molecular Medicine, Microbiology and Immunology, and Infectious Diseases
Deputy Associate Dean for Research, Office of Research
Director, General Clinical Research Center
Email: chmccall@wfubmc.edu
Education:
Wake Forest University Medical School (then Bowman Gray School of Medicine), MD, 1961
Harvard Medical School, Boston City Hospital, Residency 1961-1963
Center for Disease Control, Epidemic Intelligence Officer 1963-1965
Harvard Medical School, Fellowship, Infectious Diseases 1966-68
The Royal Society of Medicine (London), Fellowship, 1973
Board Certification:
American Board of Internal Medicine, 1968
American Board of Internal Medicine - Infectious Disease, 1972
American Board of Internal Medicine - Allergy and Immunology, 1974
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Research Interests: The molecular events that control the inflammatory components of innate immunity.
Current Research:
Dysregulation of innate immunity, which is controlled by the Toll-like receptors of innate immunity, is crucially involved in severe and life-threatening systemic infections in animals and humans. We investigate the regulation of several of the important genes associated with these highly lethal diseases, which account for the major cause of death in intensive care units throughout the world. Our present focus is on intranuclear events that modify chromatin and binding of activator and repressor factors that interact with the proximal promoters of genes that regulated innate immunity and inflammation. We are testing whether the NFkB protein, RelB, acts as a negative feed back mechanism that disrupts the proximal promoters of acute inflammatory genes that initiate sepsis and other forms of systemic inflammation with multi-organ failure.
Recent Publications:
McCall CE, Yoza BK. Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med. 2007 Apr 15;175(8):763-7. Epub 2007 Jan 25.
Yoza BK, Hu JY, Cousart SL, Forrest LM, McCall CE. Induction of RelB Participates in Endotoxin Tolerance. J Immunol. 2006 Sep 15;177(6):4080-5.
Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM. The pathogenesis of pulmonary contusion: an open chest model in the rat. J Trauma. 2006 Jul;61(1):32-44; discussion 44-5.
Chan C, Li L, McCall CE, Yoza BK Endotoxin Tolerance Disrupts Chromatin Remodeling and NFKB Transactivation of the IL-1 β promoter. J Immunol. 175: 461-8, 2005.
Mueller LP, Yoza BK, Neuhaus K, Loeser CS, Cousart S, Chang MC, Meredith JW, Li L, McCall CE. Endotoxin-adapted septic shock leukocytes selectively alter production of sIL-1RA and IL-1beta. Shock. 2001 Dec;16(6):430-7.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine
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