Nilamadhab Mishra, MD

Assistant Professor, Internal Medicine (Rheumatology)

Email: nmishra@wfubmc.edu

Education:

M.K.C.G. Medical College, Berhampur, India, MD, 1989

All India Institute of Medical Sciences, New Delhi, Residency, 1989-96

Wake Forest University School of Medicine, Fellowship, 1996-2001

Current Research:

Dr. Mishra's research interests include epigenetics, chromatin remodeling, transcriptional regulation, gene expression and identifying therapeutic targets by proteomics in lupus. He believes that the histone modification circus comprises balancing acts fundamental to human biology and diseases. He recently demonstrated that histone deacetylase inhibitors such as trichostatin A and/or related compounds suberoylanilide hydroxamic acid (SAHA) are potential candidates for the treatment of human lupus. This is the first compound identified which modulates the expression of several skewed genes that are associated with immunopathogenesis of lupus. His goal is to develop new therapeutic targets for the treatment and prevention of SLE.

Recent Publications:

Galav V, Mishra N, Dubey R, Rajukumar K, Pitale SS, Shrivastav AB, Pradhan HK. Pathogenicity of an Indian isolate of bovine viral diarrhea virus 1b in experimentally infected calves. Res Vet Sci. 2007 Mar 23.

Mishra V, Mishra N. Informed consent: are we deluding ourselves? A randomized controlled study. BJU Int. 2007 Apr;99(4):941.

Mishra N, Gupta PN, Mahor S, Khatri K, Goyal AK, Vyas SP. Liposomes as adjuvant for combination vaccines. Indian J Exp Biol. 2007 Mar;45(3):237-41.

Lee S, Giles D, Goldsman D, Cook DA, Mishra N, McCarthy B. Reproductive health services discrete-event simulation. AMIA Annu Symp Proc. 2006;1001.

Garcia BA, Hake SB, Diaz RL, Kauer M, Morris SA, Recht J, Shabanowitz J, Mishra N, Strahl BD, Allis CD, Hunt DF. Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem. 2007 Mar 9;282(10):7641-55. Epub 2006 Dec 28.

Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine