R. Duncan Hite, Ph.D.
Associate Professor, Internal Medicine-Pulmonary/Critical Care

Email: dhite@wfubmc.edu

Education:    

  See below.

Research Interests:

I am currently board certified in internal medicine, pulmonary disease and critical care medicine.  After completing my undergraduate and medical school education in Texas, I received my internal medicine residency training at the University of Virginia in Charlottesville, Virginia.  My clinical fellowship training in Pulmonary and Critical Care Medicine was performed at the University of California, San Diego, and to enhance my research skills, I completed additional training as a research fellow at Scripps Research Institute in San Diego. 

I have been a member of the faculty at Wake Forest University Health Sciences since 1994, and currently hold the position of Associate Professor of Medicine in the Section of Pulmonary and Critical Care Medicine.  My areas of clinical and research interest are general critical care with specific emphasis in acute respiratory failure, mechanical ventilation, ARDS, shock, sepsis and pneumonia.  I hold the position of Director of Medical Intensive Care and Co-Director of Critical Care Research.  As a tertiary care level medical center, we provide state of the art care critical care for a broad scope of critically ill patients including local residents of Winston-Salem and patients who are transferred from communities within our region including all of North Carolina and southern Virginia.  In addition, we provide opportunities for our patients to participate in ongoing clinical research studies that provide novel new therapies.  These studies are sponsored by a variety of agencies including the National Institutes of Health (NIH) and are held to the highest standards for ethics and patient safety. 

My responsibilities and interests also include the outpatient and inpatient management of patients with various forms of pulmonary vascular disease (pulmonary hypertension, pulmonary embolus, etc).  I currently serve as the Director of the Pulmonary Vascular Disease Clinic which receives referrals from physicians throughout our region including North Carolina, South Carolina and Virginia. 

Publications:

Hite RD, Seeds MC, Jacinto RB, Grier BL, Waite BM, Bass DA. Lysophospholipid and fatty acid inhibition of pulmonary surfactant: non-enzymatic models of phospholipase A2 surfactant hydrolysis. Biochim Biophys Acta. 2005 Dec 30;1720(1-2):14-21.

Hite RD, Seeds MC, Safta AM, Jacinto RB, Gyves JI, Bass DA, Waite BM. Lysophospholipid generation and phosphatidylglycerol depletion in phospholipase A(2)-mediated surfactant dysfunction.  Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L618-24.

Hite RD, Seeds MC, Bowton DL, Grier BL, Safta AM, Balkrishnan R, Waite BM, Bass DA. Surfactant phospholipid changes after antigen challenge: a role for phosphatidylglycerol in dysfunction. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L610-7.

Seeds MC, Bowton DL, Hite RD, Gyves JI, Bass DA. Human eosinophil group IID secretory phospholipase A2 causes surfactant dysfunction. Chest. 2003 Mar;123(3 Suppl):376S-7S.

Morris PE, Hite RD, Ohl C. Relationship between the inflammation and coagulation pathways in patients with severe sepsis: implications for therapy with activated protein C. BioDrugs. 2002;16(6):403-17.  

Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine