Kevin P. High, MD
Associate Professor, Internal Medicine (Infectious Diseases and Hematology/Oncology)
Telephone: (336) 716-4584
Fax: (336) 716-3825
Email: khigh@wfubmc.edu
Education:
- Bucknell University, BS, 1982
- University of Virginia, MD, 1986
- Wake Forest University, MSc, 1998
Research Interests: Mechanisms and Clinical Relevance of Immune Senescence
Current Research:
Our laboratory is focused on translational research of age-related changes in immune function, termed immune senescence. Our mechanistic studies utilize murine animal models and human subjects and center primarily on regulation of the inflammatory response mediated by fatty acids and other lipid mediators, strategies to enhance vaccine responses in older adults, and elucidating immune mechanisms that remain intact into advanced age that might exploited to enhance host defenses. We have active collaborations in Microbiology/Immunology and in the School of Veterinary Medicine at Virginia Tech.
Recent Publications:
Monjazeb AM, High KP, Koumenis C, and Chilton FH. Inhibitors of Arachidonic Acid Metabolism Act Synergistically to Signal Apoptosis in Neoplastic Cells. Prostaglandins, Leukotrienes Other Lipids, In Press.
High KP, Trader M, Pahor M, and Loeb M. Intra-Individual Variability and the Effect of Acute Illness on Immune Senescence Markers. J Am Geriatr Soc, In press.
High KP. The importance of geriatric-specific instruments and functional status assessment in infectious diseases research: time to start preaching to the congregation instead of the choir. J Am Geriatr Soc. 2004 Oct;52(10):1768-70. Review.
High KP. Infection as a cause of age-related morbidity and mortality.
Ageing Res Rev. 2004 Jan;3(1):1-14. Review.
High KP, Sinclair J, Easter LH, Case D, Chilton FH. Advanced age, but not anergy, is associated with altered serum polyunsaturated fatty acid levels. J Nutr Health Aging. 2003;7(6):378-84.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine