K. Bridget Brosnihan, PhD

Professor, Surgical Sciences-General (Hypertension and Vascular Disease Center) and Physiology & Pharmacology

Telephone: (336) 716-2795
Fax: (336) 716-2456

Email: bbrosnih@wfubmc.edu

Education:

• College of St. Mary, BS, 1965
• Creighton University, MS, 1970
• Case Western Reserve University Medical School, PhD, 1974

Research Description: Neuroendocrine aspects of hypertension, vascular biology, pregnancy and hormone replacement.

Current Research:

Her laboratory studies the role of hormones in the control of blood pressure and vascular reactivity. She is interested in studying the role of estrogen in blood pressure control and blood pressure regulation during normal and preeclamptic pregnancy. She uses physiological and pharmacological approaches to study the contractile state of vascular reactivity. Biochemical methods allow the measurement of tissue and circulating levels of neuroendocrine hormones. Research approaches in her laboratory study the mechanism of synthesis and secretion of angiotensin peptides from a number of local tissues. Dr. Brosnihan has published over 18 chapters and 95 papers. She has maintained an uninterrupted record of funding from the National Heart, Lung, and Blood Institute of the NIH from 1984.

Recent Publications:

Neves LA, Averill DB, Ferrario CM, Aschner JL, Brosnihan KB. Vascular responses to Angiotensin-(1-7) during the estrous cycle. Endocrine. 2004 Jul;24(2):161-5.

Seely EW, Brosnihan KB, Jeunemaitre X, Okamura K, Williams GH, Hollenberg NK, Herrington DM. Effects of conjugated oestrogen and droloxifene on the renin-angiotensin system, blood pressure and renal blood flow in postmenopausal women. Clin Endocrinol (Oxf). 2004 Mar;60(3):315-21.

Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB, Ferrario CM. Upregulation of Angiotensin-Converting Enzyme 2 After Myocardial Infarction by Blockade of Angiotensin II Receptors. Hypertension. 2004 Mar 8 [Epub ahead of print]

Modrall JG, Sadjadi J, Brosnihan KB, Gallagher PE, Yu CH, Kramer GL, Bernstein KE, Chappell MC. Depletion of tissue angiotensin-converting enzyme differentially influences the intrarenal and urinary expression of angiotensin peptides. Hypertension. 2004 Apr;43(4):849-53.

Chappell MC, Gallagher PE, Averill DB, Ferrario CM, Brosnihan KB. Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2.Lewis rat. Hypertension. 2003 Oct;42(4):781-6.