Current Research:
The focus of my research is in Osteoarthritis. We are looking at the IGF-1 signaling pathways in the chondrocyte and the decrease in the chondrocyte’s response to IGF-1 that occurs with age and OA. Included in this study is the role of age-related oxidative stress and how it contributes to the decreased IGF-1 response of the chondrocyte. With this project I work with human, non-human primate and bovine primary chondrocytes. Presentations: OARSI World Congress on Osteoarthritis Cravero, J.D., Carlson, C.S., Loeser, R.F. "THE IGF-1 SIGNALING INHIBITOR TRB3 IS INCREASED IN OA CHONDROCYTES" December 9, 2007. Podium Presentation. Publications: Manuscript
Starkman, B.G., Cravero, J.D., DelCarlo, M. Jr., Loeser, R.F. IGF-1 stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI3-kinase pathway but not ERK MAPK. Biochem. J. (2005) 389: 723-729. |