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Current Research:
My current research involves understanding how fetal defects in fatty acid oxidation can cause liver disease in a pregnant mother. Work from Dr. Ibdah's laboratory and others have documented that pregnant women develop liver disease while carrying fetuses that are deficient in a specific fatty acid oxidation enzyme, long chain 3-hydroxyacyl Co-A dehydrogenase (LCHAD). Although the association between this fetal defect and liver disease in the pregnant mother has been well established, little is known about the molecular mechanisms underlying this fetal-maternal interaction. I am in the process of generating a mouse model for this human disease in order to gain insight into the underlying molecular mechanisms of this fascinating fetal-maternal interaction. Unlocking and understanding the molecular mechanisms underlying this disorder may prevent the potentially fatal neonatal and maternal outcome of this disorder.
Publications:
Ibdah JA, Perlegas P, Zhao Y, Angdisen J, Borgerink H, Shadoan MK, Wagner JD, Matern D, Rinaldo P, Cline JM. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology. 2005 May;128(5):1381-90.
Angdisen J, Moore VD, Cline JM, Payne RM, Ibdah JA. Mitochondrial trifunctional protein defects: molecular basis and novel therapeutic approaches. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Mar;5(1):27-40. Review.
Ozbun LL, Martinez A, Angdisen J, Umphress S, Kang Y, Wang M, You M, Jakowlew SB. Differentially expressed nucleolar TGF-beta1 target (DENTT) in mouse development. Dev Dyn. 2003 Mar;226(3):491-511.
Kang Y, Ozbun LL, Angdisen J, Moody TW, Prentice M, Diwan BA, Jakowlew SB. Altered expression of G1/S regulatory genes occurs early and frequently in lung carcinogenesis in transforming growth factor-beta1 heterozygous mice. Carcinogenesis. 2002 Jul;23(7):1217-27.
Martinez A, Ozbun LL, Angdisen J, Jakowlew SB. Expression of differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) in adult mouse tissues. Dev Dyn. 2002 Jun;224(2):186-99.
Poster Presentation:
Long Chain 3-Hydroxyacyl-CoA Defect in Mice Is Embryonic Lethal and Causes Male Subfertility in Heterozygous Mice
2007 Pediatric Academic Societies’ Annual Meeting in Toronto, Canada, May 5-8
Book Chapters:
Chapter 32 - Inborn Errors of Metabolism Jerry Angdisen, Majed Dasouki and Jamal Ibdah Liver Disease in Children (3rd Edition) Edited by Frederick J. Suchy, Ronald J. Sokol, William F. Balistreri Hardback (ISBN-13:9780521856577) Published - June 2007 Cambridge University Press
Chapter 6 - Acute Fatty Liver of Pregnancy Jerry Angdisen and Jamal Ibdah Maternal Liver Disease Edited by Jamal Ibdah. ISBN: 1-58706-192-9, Published: 2007-05-01. Landes Bioscience
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine
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