Current Research:
The focus of my research is the role of reactive oxygen species (ROS) in mediating cartilage degradation in osteoarthritis (OA). More specifically, I am studying the α5β1 integrin intracellular signaling pathway in chondrocytes that results in an upregulation of matrix metalloproteinases (MMPs), or cartilage ECM degrading enzymes, when stimulated. We have recently shown that endogenous ROS are required for α5β1 integrin stimulated MMP production. Currently, I am working to identify the redox sensitive signaling protein in this pathway that is oxidized directly by ROS and the mechanism by which this occurs. This investigation will help to clarify the molecular basis of OA development.
Honors and Awards:
2004 The Carleton College Pat Lamb award
2000-2003 AVCA(American Volleyball Coaches Association) All Academic Award
Publications:
Del Carlo, M., Schwartz, D., Erickson, E.A., and R. F. Loeser. The endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte MMP production by fibronectin fragments. Free Rad. Bio. Med. 2007 May 1;42(9):1350-8.
Grant Support:
2006 – 2007 Ruth L. Kirschstein National Research Service Award
T32 GM063485 McPhail (PI)
NIH/NIGMS
Training Program in Molecular Medicine
2004-2005 Post-baccalaureate Intramural Research Training Award
NIH NHGRI
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