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Research Interests: Vitamin K, Vitamin K-Dependent Proteins and Warfarin Metabolism and Function
Current Research:
Dr. Wallin's research is focused in the area of Vitamin K and vitamin K metabolism. Coumadin, a widely used anticoagulant, is an antagonist to vitamin K. This fat-soluble vitamin is essential for hepatic biosynthesis f certain coagulation factors and also six to eight extrahepatic proteins. Two of these proteins, osteocalcin and matrix G1a protein, are present in bone and matrix, G1a protein is also present in cartilage. D. Wallin's laboratory has developed a system to study the molecular mechanisms of Coumadin action. He is currently isolating the Coumadin-sensitive enzyme present in the vitamin K cycle with a goal to gain knowledge for the better design of anticoagulant drugs and to reveal the molecular cause of Coumadin resistance.
Recent Publications:
Garcia-Espinosa MA, Wallin R, Hutson SM, Sweatt AJ. Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids. J Neurochem. 2007 Mar;100(6):1458-68.
Islam MM, Wallin R, Wynn RM, Conway M, Fujii H, Mobley JA, Chuang DT, Hutson SM. A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex. J Biol Chem. 2007 Apr 20;282(16):11893-903. Epub 2007 Feb 21.
Wajih N, Hutson SM, Wallin R. Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction. J Biol Chem. 2007 Jan 26;282(4):2626-35. Epub 2006 Nov 23.
Yennawar NH, Islam MM, Conway M, Wallin R, Hutson SM. Human mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysis. J Biol Chem. 2006 Dec 22;281(51):39660-71. Epub 2006 Oct 18.
Wajih N, Hutson SM, Wallin R. siRNA silencing of calumenin enhances functional factor IX production. Blood. 2006 Dec 1;108(12):3757-60. Epub 2006 Aug 10.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine
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