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Research Interests:
As an expert in the field of angiogenesis, my research is focused on the molecular and cellular biology of the vascular system, especially on vascular growth factors and their receptors.
Current Research:
rior studies conducted by Dr. Soker showed that supplementation of Vascular Endothelial Growth Factor (VEGF) enhanced engineered tissue vascularization and Nerve Growth Factor (NGF) induced axonal regeneration. At the Wake Forest Institute for Regenerative Medicine, Dr. Soker is developing new approaches to enhance the growth of blood vessels and nerves into the engineered or regenerated tissue by: 1) Incorporation of angiogenic and neurogenic factors in the bioengineered tissue, 2) Seeding the scaffolds of the engineered tissue with endothelial or neuronal progenitor cells; and 3) Pre-vascularization of scaffolds prior to cell seeding.
Recent Publications:
Bartsch G Jr, Eggert K, Soker S, Fiedler W, Laack E, Volkmer BG, Gschwend J, Bokemeyer C, Hautmann R, Schuch G. Urologe A. 2007 Jul 13.
Soker S, Cakmak S, Olmez G, Buyukbayram H, Nergiz Y. Investigation of the toxic effects of ropivacaine corneal endothelium by the impression cytological method. Saudi Med J. 2007 Jul;28(7):1018-20.
De Coppi P, Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007 Jan;25(1):100-6. Epub 2007 Jan 7.
Amiel GE, Komura M, Shapira O, Yoo JJ, Yazdani S, Berry J, Kaushal S, Bischoff J, Atala A, Soker S. Engineering of blood vessels from acellular collagen matrices coated with human endothelial cells. Tissue Eng. 2006 Aug;12(8):2355-65.
Atala A, Bauer SB, Soker S, Yoo JJ, Retik AB. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006 Apr 15;367(9518):1241-6.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine
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