Peter A. Antinozzi, Ph.D.

Assistant Professor of Biochemistry and Internal Medicine (Section of Molecular Medicine)

Additional Affiliations: Diabetes Center; Graduate

Faculty(Biochemistry, Molecular Medicine, Molecular Genetics)

Email: pantinoz@wfubmc.edu

Education:

B.S. - Chemistry and Microbiology (1985-1989) University of Florida, Gainesville, FL
Ph.D. - Cell and Molecular Biology (1992-1999) University of Texas, Southwestern, Dallas, TX

Research Fellow - Clinical Biochemistry (1999-2002) University of Geneva, Geneva, Switzerland
Research Fellow - Cellular Biophysics (2002-2004) Memorial Sloan-Kettering Cancer Center, New York, NY
Research Faculty - Physiology and Cellular Biophysics (2004-2007) Columbia University, New York, NY

Research Interests:

Advances in high-throughput genotyping technologies and large collaborative efforts which combine genetic datasets have brought to light several novel candidate genes involved in a variety of diseases. In particular, studies of complex trait diseases such as diabetes and cardiovascular disease have been great beneficiaries of these efforts and a number of highly replicated loci have been identified. The bottleneck in translating these findings towards clinical intervention is determining the causative mechanisms of the allelic variants within these loci. To this end, one of the primary goals of my laboratory is to leverage clinically relevant genetic data with functional data at the cellular level.

Current Research:

Functional mapping. One of our current initiatives is "functional mapping of diabetes-susceptibility loci" to identify novel genes involved in diabetes. In brief, we systematically dissect clinically relevant chromosome regions with molecular biology strategies that alter the expression of candidate genes. Expression of specific allelic variants and/or gene knockdown (via RNA interference methods) are functionally assessed by a panel of cell-based functional assays.

Other research interests include metabolism-secretion coupling, beta-cell transcription factors, and the mechanisms of antigen presentation in regards to type I diabetes.

Recent Publications:

Peter A. Antinozzi, Alejandro Garcia-Diaz, Chuan Hu, and James E. Rothman. 2006. Functional mapping of disease-susceptibility loci using cell biology. Proc. Nat. Acad. Sci. 103:3698-3703.

Wang H, Iezzi M, Theander S, Peter A. Antinozzi, Gauthier BR, Halban PA, Wollheim CB. 2005. Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. Diabetologia 8(4):720-31.

Wang, H., Maechler, P., Peter A. Antinozzi, Herrero, L., Hagenfeldt-Johansson, K. and Wollheim, C.B. 2003. The transcription factor SREBP-1c is instrumental in the development of pancreatic b-cell lipotoxicity. J. Biol.Chem. 278:16622-16629.

Peter A. Antinozzi, Hisamitsu Ishihara, Christopher B. Newgard, Claes, B. Wollheim. 2002 Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta-cell: A survey of four fuel-secretagogues. J. Biol. Chem. 277:11746-11755.

Blanca Rubí, Peter A. Antinozzi, Pierre Maechler, Laura Herrero, Hisamitsu Ishihara, Guillermina Asins, Dolors Serra, Claes B. Wollheim, Fausto G. Hegardt. 2002. Adenovirus-mediated overexpression of liver carnitine palmitoyl transferase I in INS1E cells. Effects on cell metabolism and insulin secretion. Biochem. J. 364:219-226.

Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine