Nilamadhab Mishra, MD

Assistant Professor, Internal Medicine (Rheumatology)

Email: nmishra@wfubmc.edu

Education:

M.K.C.G. Medical College, Berhampur, India, MD, 1989

All India Institute of Medical Sciences, New Delhi, Residency, 1989-96

Wake Forest University School of Medicine, Fellowship, 1996-2001

Current Research:

Dr. Mishra's research interests include epigenetics, chromatin remodeling, transcriptional regulation, gene expression and identifying therapeutic targets by proteomics in lupus. He believes that the histone modification circus comprises balancing acts fundamental to human biology and diseases. He recently demonstrated that histone deacetylase inhibitors such as trichostatin A and/or related compounds suberoylanilide hydroxamic acid (SAHA) are potential candidates for the treatment of human lupus. This is the first compound identified which modulates the expression of several skewed genes that are associated with immunopathogenesis of lupus. His goal is to develop new therapeutic targets for the treatment and prevention of SLE.

Recent Publications:

Garcia BA, Busby SA, Shabanowitz J, Hunt DF, Mishra N. Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition. J Proteome Res. 2005 Nov-Dec;4(6):2032-42.

Reilly CM, Mishra N, Miller JM, Joshi D, Ruiz P, Richon VM, Marks PA, Gilkeson GS. Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid. J Immunol. 2004 Sep 15;173(6):4171-8.

Mishra N, Reilly CM, Brown DR, Ruiz P, Gilkeson GS. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. J Clin Invest. 2003 Feb;111(4):539-52.

Mishra N, Brown DR, Olorenshaw IM, Kammer GM. Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2628-33. Epub 2001 Feb 20.

Kammer GM, Mishra N. Systemic lupus erythematosus in the elderly. Rheum Dis Clin North Am. 2000 Aug;26(3):475-92.

Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine