Larry Daniel, PhD

Professor, Biochemistry

Email: ldaniel@wfubmc.edu

Education:

Western Kentucky University, BS, 1973

Western Kentucky University, MS, 1975

University of Tennessee - Memphis, PhD, 1978

Research Interests:

Signaling pathways involving phospholipases and protein kinases are critical to cell growth control. We are studying alterations in these pathways in cancer and inflammation.

Current Research:

Phospholipids are now known to be important molecules in the generation of second-messengers during signal-transduction in cellular responses to hormones and growth factors. My laboratory is studying the metabolic pathways responsible for forming lipid-derived second-messengers and the mechanism of action of these mediators. We have previously shown that Phospholipase D is involved in the stimulation of Raf-1 and in the stimulation of prostaglandin H synthase, type 2 (PGHS-2). Current studies are to determine the signalling pathways regulating PGHS-2 and how they become altered in ovarian cancer. A second project is studying the role of phospholipase D in neutrophil responses to inflammatory stimuli. In this project the primary interest is in the signalling pathways regulating phospholipase A2.

Recent Publications:

Chen YQ, Berquin IM, Daniel LW, Edwards IJ, O'Flaherty JT, Thomas MJ, Tooze JA, Wykle B. Omega-3 fatty acids and cancer risk. JAMA. 2006 Jul 19;296(3):282; author reply 282. No abstract available.

Allen EE, Fetrow JS, Daniel LW, Thomas SJ, John DJ. Algebraic dependency models of protein signal transduction networks from time-series data. J Theor Biol. 2006 Jan 21;238(2):317-30. Epub 2005 Jul 5.

Edwards IJ, Berquin IM, Sun H, O'flaherty JT, Daniel LW, Thomas MJ, Rudel LL, Wykle RL, Chen YQ. Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin. Clin Cancer Res. 2004 Dec 15;10(24):8275-83.

Grab LT, Kearns MW, Morris AJ, Daniel LW. Differential role for phospholipase D1 and phospholipase D2 in 12-O-tetradecanoyl-13-phorbol acetate-stimulated MAPK activation, Cox-2 and IL-8 expression. Biochim Biophys Acta. 2004 Feb 27;1636(1):29-39.

O'Flaherty JT, Rogers LC, Chadwell BA, Owen JS, Rao A, Cramer SD, Daniel LW. 5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism. Cancer Res. 2002 Dec 1;62(23):6817-9.

Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine