Research Interests: Dr. Kucer’s laboratory is interested in the synthesis and testing of novel chemotherapeutic agents that potentially have dual mechanisms of action and can overcome drug resistance in order to maximize tumor cell cytotoxicity. Current Research: My current research centers on the signaling mechanisms in neoplastic cells and how these pathways are affected by cancer chemotherapy drugs. We are also interested in novel approaches to enhance drug delivery and circumvent tumor cell drug resistance. Presently, we are conjugating nucleoside analogs to phospholipids molecules. These new chemical entities have proven to be effective chemotherapy agents in cell culture. Recent Publications: Lentz SS, Miller BE, Kucera GL, Levine EA. Intraperitoneal hyperthermic chemotherapy using carboplatin: A phase I analysis in ovarian carcinoma. Gynecol Oncol. 2007 May 9; Guddneppanavar R, Choudhury JR, Kheradi AR, Steen BD, Saluta G, Kucera GL, Day CS, Bierbach U. Effect of the Diamine Nonleaving Group in Platinum-Acridinylthiourea Conjugates on DNA Damage and Cytotoxicity. J Med Chem. 2007 May 3;50(9):2259-2263. Epub 2007 Apr 5. Tomlinson JT, Park G, Misenheimer JA, Kucera GL, Hesp K, Manderville RA. Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue. Org Lett. 2006 Oct 12;8(21):4951-4. Barnes AP, Miller BE, Kucera GL. Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells. Gynecol Oncol. 2007 Feb;104(2):443-50. Epub 2006 Sep 22. Guddneppanavar R, Saluta G, Kucera GL, Bierbach U. Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine. J Med Chem. 2006 Jun 1;49(11):3204-14. Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine |