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Research Interests:
Artery wall remodeling in response to atherosclerosis and arterial injury
Restenosis following vascular reconstruction
Bioengineering of blood vessels
Functional genomics in artery wall biology
Current Research:
The Vascular Biology Laboratory of the Department of General Surgery is funded by the NIH, Industry, and Intramural grants (RL Geary, PI) to investigate mechanisms of recurrent lumen narrowing at sites of arterial reconstruction (restenosis). To this end, we have recently characterized the response to angioplasty and intra-arterial stenting in a unique nonhuman primate model of atherosclerosis. Current studies are focused on the correlation between changes in artery wall geometry and lumen narrowing after angioplasty. The importance of cell-matrix adhesive interactions in restenosis is being addressed in blocking experiments using antagonists of specific cell-surface integrins and non-integrin receptors for extra-cellular matrix components. cDNA arrays are being employed to profile changes in gene expression accompanying artery wall remodeling in nonhuman primates. More recently, we have begun to collaborate with colleagues in regenerative medicine to explore the use of circulating and marrow-derived progenitor cells and novel vascular scaffolding materials to create bioengineered blood vessels for vascular replacement therapy.
Recent Publications:
Corriere MA, Suave KJ, Ayerdi J, Craven BL, Stafford JM, Geary RL, Edwards MS. Vena cava filters and inferior vena cava thrombosis. J Vasc Surg. 2007 Apr;45(4):789-94.
Piercy KT, Ayerdi J, Geary RL, Hansen KJ, Edwards MS. Acute pancreatitis: A complication associated with rheolytic mechanical thrombectomy of deep venous thrombosis. J Vasc Surg. 2006 Nov;44(5):1110-3.
Edwards MS, Craven BL, Stafford J, Craven TE, Sauve KJ, Ayerdi J, Geary RL, Hansen KJ. Distal embolic protection during renal artery angioplasty and stenting. J Vasc Surg. 2006 Jul;44(1):128-35.
Adams LD, Geary RL, Li J, Rossini A, Schwartz SM. Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap. Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):319-25.
Igase M, Strawn WB, Gallagher PE, Geary RL, Ferrario CM. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1013-9.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine
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