Research Interests: Obstetrical Anesthesia, Pain Research Current Research: The focus of our research is understanding neuroplasticity in the spinal cord as it relates to the pharmacology of analgesia. This involves investigation of neural circuitry intrinsic to the cord as well as neural and hormonal modulation of this circuitry in the normal state and following peripheral nerve injury. Current projects examine the mechanisms underlying the estrogen dependent sex difference in cholinergic analgesia and the signals, which transform the circuitry, activated by a2-adrenergic agonists following peripheral nerve injury. In addition to fundamental research, we utilized the GCRC heavily for translational clinical studies. Recent Publications: Clayton BA, Hayashida KI, Childers SR, Xiao R, Eisenach JC. Oral Donepezil Reduces Hypersensitivity after Nerve Injury by a Spinal Muscarinic Receptor Mechanism. Anesthesiology. 2007 May;106(5):1019-1025. Yan T, Liu B, Du D, Eisenach JC, Tong C. Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function. Anesth Analg. 2007 May;104(5):1246-50, tables of contents. Romero-Sandoval A, Eisenach JC. Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology. 2007 Apr;106(4):787-94. Hayashida K, DeGoes S, Curry R, Eisenach JC. Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology. 2007 Mar;106(3):557-62. Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC. Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology. 2007 Feb;106(2):312-22. Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine |