Research Interests: Effect of antenatal steroids on fetal and adult cardiovascular development. Effect growth hormone on cerebral vascular reactivity aged rats. Effect of PPAR agonists on cerebral vascular function in aged rats. Effect of PPAR agonists on insulin resistance/metabolic syndrome in young and aged animals. Effect of cooling on digital artery function in healthy and diabetic animals Neuronal regulation of vascular tone. Effect of insulin resistance/metabolic syndrome on inferior mesenteric ganglion activity. Effect of aging on venous function. Current Research: Effect of antenatal steroids on fetal and adult cardiovascular development. Effect growth hormone on cerebral vascular reactivity aged rats. Effect of PPAR agonists on cerebral vascular function in aged rats. Effect of PPAR agonists on insulin resistance/metabolic syndrome in young and aged animals. Effect of cooling on digital artery function in healthy and diabetic animals. Publications: Gupta M, Greenberg CS, Eckman DM, Sane DC. Arterial Vimentin Is a Transglutaminase Substrate: A Link between Vasomotor Activity and Remodeling? J Vasc Res. 2007 May 3;44(5):339-344 Deshpande DA, Pascual RM, Wang SW, Eckman DM, Riemer EC, Funk CD, Penn RB. PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation. FASEB J. 2007 Mar 28. Shanker G, Kontos JL, Eckman DM, Wesley-Farrington D, Sane DC. Nicotine upregulates the expression of P2Y12 on vascular cells and megakaryoblasts. J Thromb Thrombolysis. 2006 Dec;22(3):213-20. Simandle SA, Kerr BA, Lacza Z, Eckman DM, Busija DW, Bari F. Piglet pial arteries respond to N-methyl-D-aspartate in vivo but not in vitro. Microvasc Res. 2005 Jul;70(1-2):76-83. Naik S, Billington CK, Pascual RM, Deshpande DA, Stefano FP, Kohout TA, Eckman DM, Benovic JL, Penn RB. Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. J Biol Chem. 2005 Mar 11;280(10):8722-32. Publications:
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