Research Interests: Identification of genes contributing to type 2 diabetes and the renal and cardiovascular complications of type 2 diabetes. Current Research: Dr. Donald W. Bowden has been involved in human genetics research for over 20 years starting with his participation in the construction of the first genetic maps of human chromosomes. Throughout his career Dr. Bowden has participated in a wide range of human genetic studies of both single gene disorders: cystic fibrosis, multiple endocrine neoplasia, retinitis pigmentosa, and maturity onset diabetes of the young, and complex diseases: Type 1 and Type 2 diabetes, autoimmune thyroid disease, recurrent otitis media, obesity, end stage renal disease, diabetic nephropathy, and diabetic cardiovascular disease. The current emphasis of his laboratory is locating and identifying genes, which contribute to common complex diseases in the general population, including understanding how genes interact with environmental risk factors to cause disease. Active projects are the search for genes that contribute to type 2 diabetes, obesity, metabolic disorders, and the renal and cardiovascular complications of type 2 diabetes. Recent Publications: Gallagher CJ, Keene KL, Mychaleckyj JC, Langefeld CD, Hirschhorn JN, Henderson BE, Gordon CJ, Freedman BI, Rich SS, Bowden DW, Sale MM. Investigation of the Estrogen Receptor-{alpha} Gene With Type 2 Diabetes and/or Nephropathy in African-American and European-American Populations. Diabetes. 2007 Mar;56(3):675-84. Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Xu J, McDonough C, Janssen B, Yard BA, van der Woude FJ, Bowden DW. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. Nephrol Dial Transplant. 2007 Jan 5; [Epub ahead of print] Lehtinen AB, Burdon KP, Lewis JP, Langefeld CD, Ziegler JT, Rich SS, Register TC, Carr JJ, Freedman BI, Bowden DW.Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. J Clin Endocrinol Metab. 2007 Jan;92(1):345-52. Epub 2006 Oct 24. Lange LA, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman BI, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet. 2006 Nov;70(Pt 6):717-25. Elbein SC, Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati FL, Kao WH.Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes. Diabetes. 2006 Oct;55(10):2909-14. Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine |