David W. Busija, PhD

Professor, Physiology & Pharmacology

Email: dbusija@wfubmc.edu

Education:

University of Pittsburgh, BS, 1972

University of Kansas, MA, 1974

University of Kansas, PhD, 1978

Current Research:

The overall direction of my research deals with factors involved in regulation of the cerebral circulation during physiological and pathological conditions and in mechanisms of brain injury following anoxic insults. Particular attention is focused on the roles of eicosanoids (products of arachidonic acid metabolism), neurotransmitter, growth factors, and nitric oxide. We have found that eicosanoids can directly influence cerebral vascular tone during a variety of conditions, and that oxygen radicals produced by the metabolism of arachidonic acid can lead to dysfunction of cerebral blood vessels and neurons. Further, we have shown that nitric oxide participates in cerebral vascular responses during neuronal activation.

Recent Publications:

Lenzser G, Kis B, Snipes JA, Gaspar T, Sandor P, Komjati K, Szabo C, Busija DW. Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. J Cereb Blood Flow Metab. 2007 Jan 10.

Hortobagyi L, Kis B, Hrabak A, Horvath B, Huszty G, Schweer H, Benyo B, Sandor P, Busija DW, Benyo Z. Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. Brain Res. 2007 Feb 2;1131(1):129-37. Epub 2006 Dec 11.

Katakam PV, Jordan JE, Snipes JA, Tulbert CD, Miller AW, Busija DW. Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide. Life Sci. 2007 Jan 23;80(7):633-7. Epub 2006 Nov 20.

Katakam PV, Jordan JE, Snipes JA, Tulbert CD, Miller AW, Busija DW. Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R920-6. Epub 2006 Sep 28. Cloning of cyclooxygenase-1b (putative COX-3) in mouse. Inflamm Res. 2006 Jul;55(7):274-8.

Kis B, Snipes JA, Gaspar T, Lenzser G, Tulbert CD, Busija DW. Cloning of cyclooxygenase-1b (putative COX-3) in mouse. Inflamm Res. 2006 Jul;55(7):274-8.

Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine