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Che-Ping Cheng, MD PhD
Professor, Internal Medicine (Cardiology)
Email: ccheng@wfubmc.edu
Education:
Nanjing Railway Medical University, MD, 1977
Wayne State University School of Medicine, PhD, 1986
Research Interests:
Research in Dr. Cheng's lab focuses on cardiovascular pathophysiology, and pharmacology; with major emphasis on cardiac dynamics (including LV and cardiomyocyte contraction, relaxation, [Ca2+] i transient, Ca2+ channel activity regulation) cellular signal transduction, and molecular alterations in health and cardiac diseases.
Current Research:
We have long interest in the determinants of cardiac performance, and the mechanisms and treatment of heart failure. We have developed a conscious instrumented animal model with pacing-induced CHF and alcoholic cardiomyopathy. We can serially examine left ventricle and myocyte structure, function, calcium transient and calcium current and related cellular signal transduction, gene expression and neurohormonal activation before and as CHF progresses, and determine different responses to drug interventions.
The current major projects are: 1) Functional response to neurohormonal activation in congestive heart failure (CHF); 2) the cardiac, cellular, molecular, and neurohormonal mechanisms of alcoholic cardiomyopathy; 3) alteration in beta3-AR mRNA expression before and after CHF: a potential mechanism of CHF; and 4) mechanism of exercise intolerance in CHF and treatment.
Recent Publications:
Cheng CP, Cheng HJ, Cunningham C, Shihabi ZK, Sane DC, Wannenburg T, Little WC. Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. Circulation. 2006 Jul 18;114(3):226-36.
Cheng CP, Wilson NM, Hallett RL, Herfkens RJ, Taylor CA. In vivo MR angiographic quantification of axial and twisting deformations of the superficial femoral artery resulting from maximum hip and knee flexion. J Vasc Interv Radiol. 2006 Jun;17(6):979-87.
Tang BT, Cheng CP, Draney MT, Wilson NM, Tsao PS, Herfkens RJ, Taylor CA. Abdominal aortic hemodynamics in young healthy adults at rest and during lower limb exercise: quantification using image-based computer modeling. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H668-76.
Cheng CP, Serviene E, Nagy PD. Suppression of viral RNA recombination by a host exoribonuclease. J Virol. 2006 Mar;80(6):2631-40.
Serviene E, Jiang Y, Cheng CP, Baker J, Nagy PD. Screening of the yeast yTHC collection identifies essential host factors affecting tombusvirus RNA recombination. J Virol. 2006 Feb;80(3):1231-41.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine |
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