K. Bridget Brosnihan, PhD

Professor, Surgical Sciences-General-Hypertension and Vascular Disease Center and Physiology & Pharmacology

Email: bbrosnih@wfubmc.edu

Education:

College of St. Mary, BS, 1965

Creighton University, MS, 1970

Case Western Reserve University Medical School, PhD, 1974

Research Description:

Neuroendocrine aspects of hypertension, vascular biology, pregnancy and hormone replacement.

Current Research:

Her laboratory studies the role of hormones in the control of blood pressure and vascular reactivity. She is interested in studying the role of estrogen in blood pressure control. She uses physiological and pharmacological approaches to study the contractile state of vascular reactivity. Biochemical methods allow the measurement of tissue and circulating levels of neuroendocrine hormones. Research approaches in her laboratory study the mechanism of synthesis and secretion of angiotensin peptides from a number of local tissues. Dr. Brosnihan has published over 18 chapters and 95 papers. She has maintained an uninterrupted record of funding from the National Heart, Lung, and Blood Institute of the NIH from 1984.

Recent Publications:

Pignone A, Del Rosso A, Brosnihan KB, Perfetto F, Livi R, Fiori G, Guiducci S, Cinelli M, Rogai V, Tempestini A, Bartoli F, Generini S, Ferrario CM, Matucci Cerinic M. Reduced circulating levels of angiotensin{inverted exclamation}V(1-7) in systemic sclerosis: a new pathway in the dysregulation of endothelial dependent vascular tone control. Ann Rheum Dis. 2007 Mar 14;

Schindler C, Brosnihan KB, Ferrario CM, Bramlage P, Maywald U, Koch R, Oertel R, Kirch W. Comparison of inhibitory effects of irbesartan and atorvastatin treatment on the renin angiotensin system (RAS) in veins: a randomized double-blind crossover trial in healthy subjects. J Clin Pharmacol. 2007 Jan;47(1):112-20.

Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM.The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study): rationale and baseline characteristics. Am J Cardiovasc Drugs. 2006;6(5):335-42.

Lange LA, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman BI, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet. 2006 Nov;70(Pt 6):717-25.

Neves LA, Chappell MC, Ferrario CM, Gallagher PE, Ganten D, Brosnihan KB. Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats. Peptides. 2006 Aug 3; [Epub ahead of print]

Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine