Post-Doctoral Fellowship

Center for Research on Reproduction and Women’s Health Department of Obstetrics and Gynecology University of Pennsylvania

Email address: Lanton@wfubmc.edu

Education:
Wake Forest University School of Medicine, Ph.D., 2008
Pennsylvania State University, BS, 2002

Research Interests:
Preeclampsia, Placental function, Effects of the renin angiotensin system on placental angiogenesis

Grants:  
2005-2007 American Heart Association, Pre-Doctoral Fellowship Effects of Angiotensin-(1-7) on Angiogenesis in the Human Placenta and Uterus during Normal and Preeclamptic Pregnancies                                 

Publications:
Anton L, Brosnihan KB. Systemic and Uteroplacental Renin Angiotensin System in Normal and Preeclamptic Pregnancies. Theraputics Advances in Cardiovascular Disease. Review. Submitted in March, 2008.

Anton L, Merrill DC, Neves LAA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of Local Chorionic Villi Ang II levels but not Ang-(1-7) in Preeclampsia. Hypertension. 2008 Apr;51(4):1066-72. Epub 2008 Feb 7.

Anton L, Merrill DC, Neves LAA, Sane DC, Brosnihan KB. Angiotensin-(1-7) Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells through the AT_1-7 Receptor. Endocrine. 2007 Oct;32(2):212-8.

Valdes G, Neves LAA, Anton L, Corthorn J, Chacon C, Germain AM, Merrill DC, Ferrario CM, Sarao R, Penninger J, Brosnihan KB. Distribution of Angiotensin-(1-7) and ACE2 in Human Placenta of Early and Term Normotensive Pregnancy and Preeclampsia. Placenta. 2006 Feb-Mar;27(2-3):200-7. Epub 2005 Apr 25. Sane DC, Anton L, Brosnihan, KB. Angiogenic Growth Factors and Hypertension. Angiogenesis. 2004;7(3):193-201.

Brosnihan KB, Neves LA, Anton L, Joyner J, Valdes G, Merrill DC. Enhanced Expression of Ang-(1-7) in Pregnancy. Brazilian Journal of Medical and Biological Research. 2004, 37:1255-1262.

Anton L, Merrill DC, Diz D, Neves LAA, Stovall K, Gallagher PE, Moorefield C, Gruver G, Ferrario CM, Brosnihan KB.  The increased shift of the Ang II/Ang-(1-7) balance in the chorionic villi from preeclamptic subjects is mediated primarily by the AT₁ receptor.  Hypertension 2007. 50:e79.  61^st Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, Tucson, AZ, September 26^th-29^th, 2007.

Brosnihan KB, Anton L, Merrill DC.  Ang-(1-7) and ACE2 in Human Pregnancy.  Physiologist 2007, 50:23. American Physiological Society: Sex Steroids and Gender in Cardiovascular-Renal Physiology and Pathophysiology, Austin, TX, August 9^th-12^th, 2007.  

Anton L, Merrill DC, Neves LA, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Increased Expression of AT₁ Receptor and Angiotensinogen mRNA and Ang II in Human Placental Chorionic Villi of Preeclamptic Pregnant Subjects. Hypertension  2006, 48(4):e95. 60^th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, San Antonio, TX, October 4^th-7^th, 2006.

Valdes G, Neves LA, Anton L, Corthorn J, Chacon C, Germain AM, Merrill DC, Sarao R, Penninger J, Ferrario CM, Brosnihan KB.  Distribution of angiotensin-(1-7) and ACE2 in Human placenta of early and term normotensive pregnancy and preeclampsia. Hypertension 2004:22(Suppl 1):S65. International Society for the Study of Hypertension in Pregnancy, Vienna, Austria, November 14^th-17^th, 2004

Poster Presentations:

Anton L, Merrill DC, Diz D, Neves LAA, Stovall K, Gallagher PE, Moorefield C, Gruver G, Ferrario CM, Brosnihan KB. The increased shift of the Ang II/Ang-(1-7) balance in the chorionic villi from preeclamptic subjects is mediated primarily by the AT1 receptor.  Eighth Annual Wake Forest University Graduate School Research Day, Wake Forest University, March 6^th, 2008.

Anton L, Merrill DC, Diz D, Neves LAA, Stovall K, Gallagher PE, Moorefield C, Gruver G, Ferrario CM, Brosnihan KB. The increased shift of the Ang II/Ang-(1-7) balance in the chorionic villi from preeclamptic subjects is mediated primarily by the AT1 receptor.  Division of Surgical Sciences Fifteenth Annual Residents’ and Fellows’ Research Day, Wake Forest University Baptist Medical Center, November 15^th, 2007.

Anton L, Merrill DC, Neves LA, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Increased Expression of AT₁ Receptor and Angiotensinogen mRNA and Ang II in Human Placental Chorionic Villi of Preeclamptic Pregnant Subjects. Seventh Annual Wake Forest University Graduate School Research Day, Wake Forest University, March 23^rd, 2007.

Anton L, Merrill DC, Neves LA, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Increased Expression of AT₁ Receptor and Angiotensinogen mRNA and Ang II in Human Placental Chorionic Villi of Preeclamptic Pregnant Subjects. Division of Surgical Sciences Fourteenth Annual Residents’ and Fellows’ Research Day, Wake Forest University Baptist Medical Center, November 2^nd, 2006.

Anton L, Merrill DC, Neves LA, Sane DC, Brosnihan KB. Angiotensin-(1-7) Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells Through the AT1-7 Receptor. Fifth Annual Wake Forest University Graduate School Research Day, Wake Forest University, March 18^th, 2005.

Anton L, Merrill DC, Neves LAA, Chen K, Sane DC, Brosnihan KB. Ang-(1-7) Inhibits Circulating Levels of Angiogenic Growth Factors in Normal Pregnant Women. Division of Surgical Sciences Twelfth Annual Residents’ and Fellows’ Research Day, Wake Forest University Baptist Medical Center, October 21^st, 2004.

Anton L, Valdés G, Neves L, Merrill DC, Brosnihan KB. Placental Distribution of Ang-(1-7) and ACE2 in Normal and Compromised Human Pregnancies.  Fourth Annual Wake Forest University Graduate School Research Day, Wake Forest University, March 26^th, 2004.

Anton L, Valdés G, Neves L, Merrill DC, Brosnihan KB. Placental Distribution of Ang-(1-7) and ACE2 in Normal and Compromised Human Pregnancies.  Division of Surgical Sciences Eleventh Annual Residents’ and Fellows’ Research Day, Wake Forest University Baptist Medical Center, November 6^th, 2003.

Oral Presentations:
Anton L. New Finding May Help Explain Development of Preeclampsia. Red Dress Seminar. Hypertension and Vascular Disease Center, Wake Forest University School of Medicine. February 29^th, 2008.

Anton L, Merrill DC, Diz D, Neves LAA, Stovall K, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. The Increased Shift of the Ang II/Ang-(1-7) Balance in the Chorionic Villi from Preeclamptic Subjects is mediated by the AT₁ Receptor. North American Society for the Study of Hypertension in Pregnancy Annual Scientific Meeting, June 29^th-July 1^st, 2007.

Anton L, Merrill DC, Neves LAA, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Increased Expression of AT₁ Receptor and Angiotensinogen mRNA and Ang II in Human Placental Chorionic Villi of Preeclamptic Pregnant Subjects. Thirteenth Annual Scientific Session of the Consortium for South Eastern Hypertension Control, September 14^th-17^th, 2006. 

Anton L, Valdes G, Neves LAA, Corthorn J, Germain AM, Merrill DC, Sarao R, Penninger J, Ferrario CM, Brosnihan KB. Distribution of Angiotensin-(1-7) and ACE2 in Human Placenta of Early and Term Normotensive Pregnancy and Preeclampsia. North American Society for the Study of Hypertension in Pregnancy Annual Scientific Meeting, August 12^th-14^th, 2005.

Travel Awards:
2007  Alumni Student Travel Award 
        Wake Forest University Graduate School of Arts and Sciences
        To attend the 61^st Annual Fall Conference and Scientific Sessions of the  
        Council for High Blood Pressure Research in Tucson, AZ, September 26-29,
        2007

2007  Merck New Investigator Award, Travel Award 
        American Heart Association, Council for High Blood Pressure
        To attend the 61^st Annual Fall Conference and Scientific Sessions
        of the Council for High Blood Pressure Research in Tucson, AZ, September
        26-29, 2007

2007  Young Investigator Travel Award North American Society for the Study
         of Hypertension in Pregnancy To attend the North American Society for
        the Study of  Hypertension in Pregnancy Annual Meeting in San Diego, CA,
        June 29-July 1, 2007.

2006  Alumni Student Travel Award Wake Forest University Graduate School of
        Arts of Sciences To attend the 60^th Annual Fall Conference and Scientific
        Sessions of the Council for High Blood Pressure Research in San Antonio,
        TX, October 4-2, 2006

2006  Clinical Science Travel Fellowship and Honorarium Consortium for South
         Eastern Hypertension Control (COSEHC) To attend the 13^th Annual
         Scientific Sessions of COSEHC in Litchfield, SC, September 14-17, 2006

2005  Young Investigator Travel Award 
        North American Society for the Study of Hypertension in Pregnancy
        To attend the North American Society for the Study of Hypertension in 
        Pregnancy Annual Meeting in Wheeling, WV, August 12-14, 2005.

2003  Silver Award Eleventh Annual Residents’ and Fellows’ Research Day 
       Division of Surgical Sciences, Wake Forest University School of Medicine