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Jeanette Bensen, M.S., Ph.D.
Assistant Professor, Epidemiology
University of North Carolina, Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Email: jbensen@med.unc.edu
Education:
Bowman Gray School of Medicine-Wake Forest University, Post-doc Fellowship, 2002-2003
Bowman Gray School of Medicine-Wake Forest University, Ph.D., 2002
University of Pittsburgh, M.S., 1985
SUNY College of Fredonia, BS, 1981
Research Interests:
My main research interest is to investigate the role of inflammation in complex disease (ex. cardiovascular disease, cancer) in well-characterized clinical or population-based sample groups with the goal being identification of risk groups for targeted intervention strategies or altered treatment methods. My research will continue to focus on genetic variation in inflammatory genes, in particular single nucleotide polymorphisms (SNP) and haplotype analysis, and gene-gene and gene-environment interaction in multiethnic epidemiologic studies. Additional interests include utilization of public genomic databases and software for genetic data analysis, as well as translational research with a focus on regulatory DNA sequence motifs and protein expression.
Publications:
Millikan RC, Newman B, Tse C-K, Moorman P, Smith LV, Labbok M, Geradts J, Bensen JT, Jackson S, Nyante S, Livasy C, Carey L, Perou CM Epidemiology of basal-like breast cancer. Breast Cancer Res Treat. 2007 Jun 20; [Epub ahead of print].
Gaudet MM, Gammon MD, Bensen JT, Sagiv SK, Shantakumar S, Teitelbaum SL, Eng SM, Neugut AI, Santella RM, Weston A. Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York. Breast Cancer Res Treat 2007; [in press].
Schroeder JC*, Bensen JT*, Su J, Mishel M, Ivanova A, Godley P, Smith G, Fontham E, Mohler J. (2006). The North Carolina – Louisiana Prostate Cancer Project (PCaP): Methods and design of a multidisciplinary population-based cohort study of racial differences in prostate cancer outcomes. Prostate. 66(11):1162-76. [*First authorship shared by Schroeder and Bensen]
Gaudet MM, Bensen JT, Olshan AF, Schroeder J, Terry MB, Eng SM, Teitelbaum SL, Britton JA, Lehman TA, Neugut AI, Ambrosone CB, Santella RM, Gammon MD. (2006). Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York. Breast Cancer Res Treat. 99(2):235-40.
Gaudet MM, Gammon MD, Santella RM, Britton JA, Teitelbaum SL, Eng SM, Terry MB, Bensen JT, Schroeder J, Olshan AF, Neuget AI, Ambrosone CB. (2005). MnSOD Val-9Ala Genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York. Cancer Causes Control. 16:1225-1234.
Sun J., Hedelin M., Zheng S.L., Adami H. O., Bensen J., Augustsson-Balter K., Chang B., Adolfsson J., Adams T., Turner A., Meyers D.A., Isaacs W.B., Xu J., Gronberg H. (2004). Interleukin-6 sequence variants are not associated with prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 13(10): 1677-9.
Zheng, S.L., Augustsson-Balter, K., Chang, B., Hedelin, M., Li, L., Adami, H.O., Bensen, J.T., Li, G., Johnasson, J.E., Turner, A.R., Adams, T.S., Meyers, D.A., Issacs, W.B., Xu, J., Gronberg, H. (2004). Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. Cancer Research 64(8):2918-22.
Bensen, J.T., Hsu, F-C., Brown, W.M., Sutton, B.S., Norris, J.M., Tracy, R.P., Jenny, N.S., Saad, M.F., Haffner, S.M., Bowden D.W., and Langefeld, C.D. (2004). Association analysis of the plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G polymorphism in Hispanics and African Americans: The IRAS Family Study. Human Heredity. 57(3):128-37.
Lindmark, F., Zheng, S., Wiklund, F., Bensen, J.T., Balter, K.A., Chan, B., Hedelin, M., Clark, J., Stattin, P., Meyers, D.A., Adami, H., Issacs, W.B., Gronberg, H., and Xu, J. (2004). The H6D polymorphism in the macrophage inhibitory cytokine gene 1 is associated with prostate cancer. J Natl Cancer Inst. 96(16):1248-54.
Hart, P.S., Wright, J.T., Savage, M., Kang, G., Bensen, J.T., Gorry, M.C., Hart, T.C. (2003). Exclusion of candidate genes in two families with autosomal dominant hypocalcified amelogenesis imperfecta. European Journal of Oral Sciences. 111(4):326-31.
Bensen, J.T., Langefeld, C.D., Hawkins, G.A., Green L.E., Mychaleckyj, J.C., Brewer, C.S., Kiger, D.S., Binford, S.M., Colicigno, C.J., Allred, D.C., Freedman, B.I., and Bowden, D.W. (2003). Nucleotide variation, haplotype structure and association of the human interleukin-1 gene cluster with end stage renal disease. Genomics. 82:194-217.
Bensen, J.T., Lange, L.A., Langefeld, C.D., Chang, B-L., Bleecker, E.R., Meyers, D.A., Xu, J. (2003). Exploring pleiotropy using principal components. BMC Genet. 2003, 4(Suppl 1):S53.
Bensen, J.T., Li, L., Langefeld, C.D., McCall, C.E., Cousart, S., Dryman, B.N., Freedman, B.I., and Bowden, D.W. (2003). Association of an IL1A 3’UTR Polymorphism with end stage renal disease and IL1α expression. Kidney International 63:1211-1219.
Bensen, J.T., Dawson, P.A., Mychaleckyj, J.C. and Bowden, D.W. (2001). Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. Journal of Interferon and Cytokine Research 21:899-904.
Fossey, S.C., Mychaleckyj, J.C., Pendleton, J.K., Snyder, J.R., Bensen, J.T., Hirakawa, S., Rich, S.S., Freedman, B.I. and Bowden, D.W. (2001). A high resolution 6.0 transcript map of the Type 2 diabetes susceptibility region on human chromosome 20. Genomics 76:45-57.
Williams R.R., Hunt S.C., Heiss, G., Province, M.A., Bensen J.T., Higgins, M., Chamberlain R.M., Ware, J. and Hopkins, P.N. (2001). Usefulness of cardiovascular family history data for population-based preventive medicine and medical research (the Health Family Tree Study and the NHLBI family Heart Study). Am J Cardiol. 87(2): 129-35.
Li, R., Bensen, J.T., Hutchinson, R.G., Province, M.A., Hertz-Picciotto, I., Sprafka, J.M. and Tyroler, A. (2000). Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) Study and the NHLBI family heart study. Genetic Epidemiology 18(3):236-50.
Bensen, J.T., Liese A.D., Rushing, J.T., Province, M., Folsom, A.R., Rich, S.S. and Higgins, M. (1999). Accuracy of proband reported family history: the NHLBI Family Heart Study (FHS). Genetic Epidemiology, 17(2):141-50.
Bensen, J.T., Li, R., Hutchinson, R.G., Province, M.A. and Tyroler, H.A. (1999). Family history of coronary heart disease and pre-clinical carotid artery atherosclerosis in African Americans and whites: the ARIC study: Atherosclerosis Risk in Communities. Genetic Epidemiology 16(2): 165-178.
Bensen, J.T., Nelson, L.H., Pettenati, M.J., Block, S.M., Brusilow, S.W., Livingstone, L.R, and Burton, B.K. (1991). The first report of management and outcome of pregnancies associated with hereditary orotic aciduria. American Journal of Medical Genetics 41: 426-31.
Burton, B.K., Pettenati, M.J., Block, S.M., Bensen, J.T. and Roach, E.S. (1989). Non-ketotic hyperglycinemia in a patient with the 9p-syndrome. American Journal of Medical Genetics 32:504-505.
Bensen, J.T., Dillard, R.G., Burton, B.K. (1988). Open spina bifida: does cesarean section delivery improve prognosis? Obstetrics and Gynecology 71(4)532-534.
Nelson, L.H., Bensen, J.T., Burton, B.K. (1987). Outcomes in patients with unusually high maternal serum alpha-fetoprotein levels. American Journal of Obstetrics and Gynecology 157(3)572-75.
Bensen, J.T., Steele, M.W. (1985). A mildly retarded woman with 46,XX/47,XX, + 18 mosaicism. American Journal of Medical Genetics 22:343-356.
ABSTRACTS
Bensen, J.T., Lange, L.A., Langefeld, C.D., Chang, B-L., Bleecker, E.R., Meyers, D.A., and Xu, J. Exploring Pleiotropy using Principal Components. Genetic Analysis Workshop 13 (GAW13), New Orleans, Louisiana, November 11-14, 2002. BMC Genet. 2003 Dec 31;4 Suppl 1:S53.
Bensen, J.T., Langefeld, C. D., Hawkins, G. A., Green, L. E., Mychaleckyj, J. C. , Brewer, C. S., Kiger, D. S., Binford, S. M., Colicigno, C. J., Allred, D., Freedman, B.I., and Bowden, D. W. Dense SNP map of Interleukin-1 gene cluster and end stage renal disease. Accepted poster presentation, the 52nd Annual Meeting of the American Society of Human Genetics, Baltimore, Maryland, October 15-19, 2002. Amer J Hum Genet Supplement 71:461.
Bensen, J.T., Dawson, P.A., Mychaleckyj, J.C. and Bowden, D.W. (2001) Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. Accepted poster presentation, the 51st Annual Meeting of the American Society of Human Genetics, San Diego, California, October 12-16, 2001. Amer J Hum Genet Supplement 69:358.
Liese, A., Evans, G., Bensen, J.T., Province, M.A., Folsom, A., Rich, S. and Higgins, M. (1997). Validation of Family History of Coronary heart Disease: The Family Heart Study (FHS) Experience. Accepted poster presentation, the 16th Annual Education Conference at the National Society of Genetic Counselors on October 25-27, 1997 in Baltimore, Maryland. Journal of Genetic Counseling, 6(4).
Li, R., Bensen, J.T., Hutchinson, R.G., Province, M.A., Tyroler, H.A. Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) study. Poster presentation, the 4th International Conference on Preventive Cardiology Jointly with the 37th Annual Meeting of the Council on Epidemiology and Prevention, American Heart Association, Montreal, Canada, June 29-July 3, 1997. Can J Cardiol 13(Suppl B);323B.
Bensen, J.T., Rushing, J., Province, M., Liese A., Folsom, A., Rich, S., Higgins, M.S. Accuracy of proband family history reporting: the Family Heart Study (FHS) experience. American Journal of Epidemiology 143(11), June 1, 1996.
Schreiner, P.J., Liao, D., Bensen, J.T., Higgins, M. Comparison of abdominal height and conventional anthropometry as predictors of lipid and hemostatic levels: the ARIC study. Poster presentation, the 35th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, March 1995. Circulation 91(3): P8.
Bensen, J.T., Tyroler, H., Province, M.A., Evans, G.W., Higgins, M., Hutchinson, R.G., Li, R., Sprafka, J.M., Heiss, G. Family history of coronary heart disease and carotid artery atherosclerosis: the ARIC and FHS studies. Poster presentation, 1994 National Society of Genetic Counselors Annual Education Conference in Montreal, Canada. Journal of Genetic Counseling 3(4):296.
Bensen, J.T., Nelson, L.H., Pettenati, M.J., Block, S.M., Brusilow, S.W., and Burton, B.K., Hereditary orotic aciduria: an association with 11;22 balanced translocation and familial inversion of chromosome 4. Poster presentation at 40th Annual Meeting of the American Society of Human Genetics, Baltimore, Maryland, November 1989. Amer J Hum Genet Supplement 45:A39.
Bensen, J.T., Burton, B.K. Imperforate anus with hypospadias: evidence for X-linked recessive inheritance. Poster Presentation, 39th Annual Meeting of the American Society of Human Genetics, New Orleans, Louisiana, October 12-15, 1988. Amer J Hum Genet Supplement 43:A39.
Bensen, J.T., Dillard, R.G., Burton, B.K. Open spina bifida: does cesarean section delivery improve prognosis? Poster presentation, 37th Annual Meeting of the American Society of Human Genetics, Philadelphia, November 2-5, 1986. Amer J Hum Genet Supplement 39:A250.
OTHER PUBLICATIONS
Bensen, J.T., Burton, B.K. Imperforate anus with hypospadias: evidence for X-linked recessive inheritance. Personal correspondence with Victor McKusick, Ninth Edition, Mendelian Inheritance in Man, March 1990.
Bensen, J.T. (June 1989). Second trimester ultrasound diagnosis of Down syndrome. North Carolina Medical Genetics Association Newsletter 7(2).
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