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Available Research Projects

Section

Mentor

Project Title

Cardiology

Applegate

Evaluation of Clinical Outcomes in Patients with Acute & Chronic Coronary Syndrome Undergoing Catheterization and PCI Procedure

Cheng

Beta3-Adrenergic Receptors and Cardiac Dysfunction in a Murine Model of Heart Failure

Cheng

Anti-Tumor Necrosis Factor-α and the Progression of Heart Failure in Rats

Cheng

Molecular Basis in the Development of Alcoholic Cardiomyopathy in Monkeys

Cheng

Mechanisms of Carvedilol in the Progression of Heart Failure: Blockade of Beta3-Adrenoceptors

Cheng

Beta3-Adrenergic Receptor Blockade on Left Ventricular Arterial Coupling and Mechanical Efficiency at Rest and during Exercise in Heart Failure

Cheng

Levosimendan: Effect Per Oral (capsule) Administration on Hemodynamics and Neurohormonal Responses (The Pharmacodynamic vs the Pharmacokinetic Relationship) Before and After CHF

Cheng

Effect of Levosimendan on Force-Frequency Relationship in Heart Failure

Herrington

Association of ABCA1 Polymorphisms and Inflammation Proteins

Herrington

Use of Thoracic CT to Estimate LV Mass

Herrington

IRACI Variants and CRP

Hundley

Detection of Cardiac Injury from Chemotherapy

Hundley

Use of Imaging to Predict Emergency Room Visits with Heart Failure

Kitzman

Upgrade of Hand-Held Echo Doppler System

Kitzman

Mechanisms of Exercise Intolerance in Diastolic Heart Failure

Kitzman

Clinical Utility of Echocardiography: Case Studies and Case Series

Watts

Clinical Reviews

Endocrinology

Calles

Obesity Effects on Parameters of the Metabolic Syndrome: A Multiethnic Comparison

Crouse

Non-invasive Evaluation of Carotid Atherosclerosis: Relation to Coronary Artery Disease

Crouse

Validation of CT and MRI of Carotid Atherosclerosis: Risk Factor Relationship

Gastroenterology

Bloomfeld

Nutritional regulation of human Crohn's disease by conjugated linoleic acid

Bloomfeld

Crohn's disease diagnosed by capsule endoscopy

Bloomfeld

The utility of IBD serologies in the diagnosis of inflammatory diseases of the colon

Bloomfeld

Virtual colonoscopy for colorectal cancer screening: An assessment of racial differences

Bloomfeld

GM-CSF in Crohn's disease: A Phase III, multicenter, double-blind, randonized, placebo-controlled retreatment study of Sargramostin in patients with active Crohn's disease and prior treatment response to Sargramostim

Bloomfeld

A pilot study of the effects of dietary soy supplementation on Crohn's disease

Bloomfeld

GM-CSF in Crohn's disease: open-label trial of Sargramostim, a recombinant human granylocyte-macrophage stimulating factor (GM-CSF), in active Crohn's disease

Bloomfeld

A multicenter, randomized, Phase 2a study of monoclonal antibody to IL-12p40 (CNTO 1275) in subjects with moderately to severely active Crohn's disease

Bloomfeld

Azathioprine in Crohn's disease: ACORDIS: A Crohn's disease optimal regimen for dosing of Imuran study

Bloomfeld

Thiopurine Methyltransferase activity is correlated with Azathioprine metabolite levels in inflammatory bowel disease patients in clinical GI practice

Bloomfeld

TREAT Registry: The Crohn's therapy resource evaluation and assessment tool

Bloomfeld

Asacol in UC: A naturalistic study of Asacol dosing patterns & outcomes in the treatment of ulcerative colitis

Bloomfeld

The efficacy of topical Metronidazole (10%) in the treatment of anorectal Crohn's disease

Bruggen

A randomized, double-blind, prospective, placebo-controlled comparison of calcium and Piroxicam for the prevention of recurrences of adenomatous colorectal polyps CPC-9801

Bruggen

A multi-center, double blind, dose ranging trial to evaluate the efficacy and safety of L-Glucose as a colon cleansing agent prior to colonoscopy LGLU-02

Dawson

lleal bile acid transporter mutations in patients with "black" pigment stones

Dawson

Colonic expression of bile acid transporter genes in normal colonic mucosa and adenomas

Koch

Nausea and vomiting of pregnancy:  gastric myoelectric activity and water load tests

Koch

Effects of calcium supplements on upper GI symptons and electrogastrogram patterns

Koch

Gastric myoelectrical activity and upper GI symptoms in patients with Type 2 diabetes mellitus

Soker/Koch

Liver regeneration studies

Christ/Koch

Gastric dysmotility and gastroparesis in animals with diabetes

Koch

Neuromuscular function of the urinary bladder

Koch

Myoelectrical activity of the urinary bladder

Levine

Genetics, hormonal, EGG, ANS, and psychosocial markers for susceptibility to the nausea of motion sickness: Implications for nausea in other contexts

Levine

High protein and ginger meals as adjuvant therapies for the delayed nausea and gastric dysrhythmia of cancer chemotherapy

Levine

Effect of enzyme supplements on meal-related symptom of dyspepsia

Levine

Psychophysiological differentiation of patients with and without anticipatory nausea of cancer chemotherapy:  Implications for nonpharmacological interventions

Levine

Effect of specific amino acids on nausea and gastric myoelectrical activity

Levine

Cognitive impairments associated with motion sickness environment

Levine

Relationships between hunger, satiety, fullness and the EGG

Levine

Stress-induced changes in appetite: EGG, ANS, and psychosocial influences on individual differences in tendencies to eat as a coping mechanism

Levine

Nausea and vomiting of pregnancy:  Potential therapeutic approaches and EGG, ANS, hormonal, and psychosocial aspects

Mishra

Conventional EUS-FNA vs. EUS-FNA + brush cytology system: What is the incremental benefits?

Mishra

EUS-FNA of esophageal wall to determine complete response after neoadjuvant therapy in esophageal cancer

Mishra

Capsace and MIB1 as predictors of complete response in patients with esophageal cancer after neoadjuvant therapy

Mishra

Heparin rinsed EUS-FNA vs. conventional EUS-FNA needle system: A prospective randomized trial

Mishra

Cytology slides alone versus entire cytology brush analysis for diagnosing malignancy in biliary structures

Mishra

EGFR receptor studies from EUS-FNA of pancreatic adenocarcinoma: A feasibility study

Mishra

Urinary cadium levels in patients with pancreatic adenocarcinoma

Weinberg

Effect of apo A-IV polymorphisms on ω-3 fatty acid absorption in humans

Weinberg

Structure and interfacial behavior of human apo A-IV

Weinberg

Effect of apolipoprotein polymorphisms on human lactation

General Internal
Medicine

Mellen

Macronutrient intake and microalbuminuria

Miller

ACS grant:  "Overcoming literacy barriers in colorectal cancer screening" (This is a randomized-controlled trial testing the ability of a multimedia, educational computer program to overcome the literacy barriers and increase colorectal cancer screening rates)

Singh

Systematic review and meta-analysis of the risk of gastrointestinal bleed with SSRIs

Wofford

Outpatient Clinic quality improvement projects - Residents may sign up for a one month elective in outpatient quality improvement

Gerontology and Geriatrics

Atkinson

Care of the vulnerable elderly educational project

Ding

Pericardial fat and the development of cardiovascular disease

Kritchevsky

Pulmonary function and inflammation in the elderly

Nicklas

Effects of diet and exercise intervention

Nicolle

The neurobiological basis of memory decline in aging

Sink

Correlates of memory disorders in older adults

Williamson

Analysis of existing data sets on factors related to health and aging

Hematology and Oncology

 

Akman

Biology of exocyclic alkylamino purine DNA adducts

Keung

Cytogenetic abnormalities in hematopoeitic stem cell transplant patients

Knovich

Inflammatory markers in thrombotic thrombocytopenic purpura

Kucera

Laboratory testing of novel chemotherapeutic agents

Levitan

Prevalence of cytogenetic abnormalities in ALL patients by ethnicity.

Levitan

MGUS/elevated B-2 microglobulin in renal failure patients.

McQuellon

Depression screening in cancer patients following cytoreductive surgery and intraperitoneal heated chemotherapy.

Owen

In vitro detection of pathologic antibodies in heparin-induced thrombocytopenia

Owen

JAK2 mutations in myeloproliferative disorders

Petty

RAR Beta 1: A novel tumor suppressor in lung carcinogenesis

Petty

Augmenting the clinical activity of epidermal growth factor receptor inhibition with receptor-selective retinoids

Porosnicu

Enhancing selective oncolytic activity of vesicular stomatitis virus by expression of suicide genes.

Porosnicu

EGFR inhibitors:  biomarkers of response and mechanisms of escape.

Infectious Disease

High

Bench research projects on the role of IL-23 and IL-17 in host defense

High

New adjuvants to improve vaccine responses in older adults - both animal and human studies are in progress

High

Chart review projects of infectious diseases in immunocompromised hosts (e.g. hematopoietic stem cell transplant recipients, leukemia/lymphoma)

Nunez

Hepatitis B in HIV co-infected patients:  impact of race on spontaneous clearance and on clinical progression

Nunez

Toxicities of antiretroviral drugs according to race