Sarah Hoffmann Lindsey, PhD
Postdoctoral Research Fellow
Education:
2007 Ph.D. - Pharmacology, Louisiana State University Health Sciences Center
2000 M.S. - Biopsychology, University of Memphis
1999 B.A. - Psychology, University of Mississippi
Laboratory Department: Hypertension and Vascular Research Center
Email: salindse@wfubmc.edu
Advisor: Dr. Mark Chappell
Current Research:
My research project addresses whether the direct effects of estrogen on the vasculature may contribute to gender differences in hypertension. Using mRen2.Lewis congenic rats, a model of hypertension which displays estrogen sensitivity, we will determine the effect of estrogen on vascular reactivity using isolated aortic rings and perfused mesenteric vessels. In addition, we will determine which estrogen receptor subtypes (α, β, and newly discovered estrogen receptor, GPR30) contribute to these effects. Additional studies will address the expression of vascular estrogen receptors and the mechanism by which estrogen alters smooth muscle cell contractility.
Publications:
Radcliffe RA, Erwin VG, Draski L, Hoffmann S, Edwards J, Deng XS, Bludeau P, Fay T, Lundquist K, Asperi W, and Deitrich RA. Quantitative trait Loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. Alcohol Clin Exp Res. 2004 28:1796-1804.
Radcliffe RA, Hoffmann SE, Deng XS, Asperi W, Fay T, Bludeau P, Erwin VG, Deitrich RA. (2004) Behavioral characterization of alcohol-tolerant and alcohol-nontolerant rat lines and an f(2) generation. Behavioral Genetics. 2004 34;(4):453-63.
Hoffmann SE and Matthews DB. Ethanol-induced impairments in spatial working memory are not due to deficits in learning. Alcoholism: Clinical and Experimental Research 2001:856-861.
Abstracts:
Lindsey SH and Songu-Mize E. Cyclic stretch decreases capacitative calcium entry in vascular smooth muscle cells from resistance and conduit vessels. Experimental Biology, The FASEB Journal 2007 21: Abstract #945.1.
Hoffmann SE, Kuriakose M, Songu-Mize E. Stretch-induced TRPC4 downregulation in RASM cells may be due to changes in intracellular calcium. Experimental Biology, The FASEB Journal 2006 20:Abstract #699.17.
Hoffmann SE, Dincer UD, Kuriakose M, Songu-Mize E. The effect of cyclic stretch on TRPC4 protein and gene expression in vascular smooth muscle cells. American Heart Association 59th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. Hypertension 2005 46: Abstract #P80
Hoffmann SE, Zhang Z, Kuriakose M, Songu-Mize E. Effect of cyclic stretch on TRPC expression and calcium mobilization. Experimental Biology, The FASEB Journal 2005 19:Abstract #LB319
Hoffmann SE, Dalrymple A, Tribe RM, and Songu-Mize E. Stretch regulates TRPC4 expression in smooth muscle cells. Experimental Biology. The FASEB Journal 2004 18:Abstract #459.411
Songu-Mize E, Hoffmann SE, Sevieux N, and Hornick C. Nitric oxide mediates regulation of the Na+, K+- ATPase by long-term stretch. American Heart Association 57th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. Hypertension 2003 42:Abstract #P261
Radcliffe RA, Hoffmann SE, Deng X-S, Bludeau P, Fay T, Asperi W, Erwin VG, Deitrich RA. Inbreeding of alcohol-tolerant (AT) and alcohol-nontolerant (ANT) rat lines and characterization of an F2 population. Research Society on Alcoholism. 2002
Hoffmann SE, Radcliffe RA, Deng X-S, Deitrich RA. The re-establishment, characterization and inbreeding of alcohol-tolerant and alcohol-nontolerant rat lines. Research Society on Alcoholism. 2002
Deng X-S, Deitrich RA, Bludeau P, Hoffmann SE. Formation of ethyl nitrite in vivo after ethanol administration. International Society for Biomedical Research on Alcoholism 11th Congress and Research Society on Alcoholism 25th Annual Scientific Meeting, Special Satellite Meeting "A Licit Drug Affair" In Honor of Dr. Richard A. Deitrich. 2002
Hoffmann SE and Matthews DB. Acute ethanol administration selectively impairs spatial working memory in a temporary and dose-dependent manner. Research Society on Alcoholism. 2000
Honors and Awards:
2007 Graduate Student Travel Award, American Society for Pharmacology and Experimental Therapeutics
2004 Young Investigator Award, Society for Experimental Biology and Medicine
2000 1st place, Graduate Student Poster Conference, University of Memphis, Department of Psychology
2000 Graduate Student Travel Award, University of Memphis, Department of Psychology